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BIBTEX RIS

Nickel-Catalyzed Biaryl Coupling of Heteroarenes and Aryl Halides/Triflates

2009; American Chemical Society; Volume: 11; Issue: 8 Linguagem: Inglês

10.1021/ol9001587

ISSN

1523-7060

Autores

J. Canivet, Junichiro Yamaguchi, Ikuya Ban, Kenichiro Itami,

Tópico(s)

Sulfur-Based Synthesis Techniques

Resumo

Ni-based catalytic systems for the arylation of heteroarenes with aryl halides and triflates have been established. Ni(OAc)(2)/bipy is a general catalyst for aryl bromides/iodides, and Ni(OAc)(2)/dppf is effective for aryl chlorides/triflates. Thiazole, benzothiazole, oxazole, benzoxazole, and benzimidazole are applicable as heteroarene coupling partners. A rapid synthesis of febuxostat, a drug for gout and hyperuricemia, is also demonstrated.

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