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INTEGRATING OBJECTIVE GENE-BRAIN-BEHAVIOR MARKERS OF PSYCHIATRIC DISORDERS
2007; Imperial College Press; Volume: 06; Issue: 01 Linguagem: Inglês
10.1142/s0219635207001465
ISSN1757-448X
AutoresEvian Gordon, Belinda J. Liddell, Kerri J. Brown, Richard A. Bryant, C. Richard Clark, Pritha Das, Carol Dobson‐Stone, Erin Falconer, Kim L. Felmingham, Gary Flynn, Justine M. Gatt, Anthony Harris, Daniel F. Hermens, Patrick J. Hopkinson, Andrew H. Kemp, Stacey A. Kuan, Illario Lazzaro, Jonson Moyle, Robert Paul, Chris Rennie, Peter R. Schofield, Thomas J. Whitford, Leanne M. Williams,
Tópico(s)Genetic Associations and Epidemiology
ResumoJournal of Integrative NeuroscienceVol. 06, No. 01, pp. 1-34 (2007) Research ReportsNo AccessINTEGRATING OBJECTIVE GENE-BRAIN-BEHAVIOR MARKERS OF PSYCHIATRIC DISORDERSEVIAN GORDON, BELINDA J. LIDDELL, KERRI J. BROWN, RICHARD BRYANT, C. RICHARD CLARK, PRITHA DAS, CAROL DOBSON-STONE, ERIN FALCONER, KIM FELMINGHAM, GARY FLYNN, JUSTINE M. GATT, ANTHONY HARRIS, DANIEL F. HERMENS, PATRICK J. HOPKINSON, ANDREW H. KEMP, STACEY A. KUAN, ILLARIO LAZZARO, JONSON MOYLE, ROBERT H. PAUL, CHRIS J. RENNIE, PETER SCHOFIELD, THOMAS WHITFORD, and LEANNE M. WILLIAMSEVIAN GORDONThe Brain Resource International Database and the Brain Resource Company, Sydney, NSW 2007, AustraliaThe Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Sydney, NSW 2145, AustraliaDiscipline of Psychological Medicine, University of Sydney, NSW 2006, AustraliaCorresponding author..., BELINDA J. LIDDELLThe Brain Resource International Database and the Brain Resource Company, Sydney, NSW 2007, AustraliaThe Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Sydney, NSW 2145, Australia, KERRI J. BROWNThe Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Sydney, NSW 2145, Australia, RICHARD BRYANTSchool of Psychology, University of NSW, Kensington, NSW 2052, Australia, C. RICHARD CLARKSchool of Psychology and Cognitive Neuroscience Laboratory, The Flinders University of South Australia, Bedford Park, South Australia, 5042, Australia, PRITHA DASThe Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Sydney, NSW 2145, AustraliaSchizophrenia Research Institute, Darlinghurst, NSW 2010, Australia, CAROL DOBSON-STONEGarvan Institute of Medical Research, NSW 2010, AustraliaPrince of Wales Medical Research Institute and University of New South Wales, NSW 2031, Australia, ERIN FALCONERThe Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Sydney, NSW 2145, AustraliaSchool of Psychology, University of NSW, Kensington, NSW 2052, Australia, KIM FELMINGHAMThe Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Sydney, NSW 2145, Australia, GARY FLYNNEarly Psychosis Intervention Program, Liverpool Hospital, Sydney, NSW 2170, Australia, JUSTINE M. GATTThe Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Sydney, NSW 2145, Australia, ANTHONY HARRISThe Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Sydney, NSW 2145, AustraliaDiscipline of Psychological Medicine, University of Sydney, NSW 2006, Australia, DANIEL F. HERMENSThe Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Sydney, NSW 2145, Australia, PATRICK J. HOPKINSONThe Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Sydney, NSW 2145, AustraliaDiscipline of Psychological Medicine, University of Sydney, NSW 2006, Australia, ANDREW H. KEMPThe Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Sydney, NSW 2145, Australia, STACEY A. KUANThe Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Sydney, NSW 2145, Australia, ILLARIO LAZZAROThe Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Sydney, NSW 2145, Australia, JONSON MOYLEThe Brain Resource International Database and the Brain Resource Company, Sydney, NSW 2007, Australia, ROBERT H. PAULUniversity of Missouri — St. Louis, Behavioral Neuroscience St. Louis, MO 63121, USA, CHRIS J. RENNIEThe Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Sydney, NSW 2145, Australia, PETER SCHOFIELDPrince of Wales Medical Research Institute and University of New South Wales, NSW 2031, Australia, THOMAS WHITFORDThe Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Sydney, NSW 2145, AustraliaThese authors equally contributed to the paper., and LEANNE M. WILLIAMSThe Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Sydney, NSW 2145, AustraliaDiscipline of Psychological Medicine, University of Sydney, NSW 2006, Australiahttps://doi.org/10.1142/S0219635207001465Cited by:21 PreviousNext AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend to Library ShareShare onFacebookTwitterLinked InRedditEmail AbstractThere is little consensus about which objective markers should be used to assess major psychiatric disorders, and predict/evaluate treatment response for these disorders. Clinical practice relies instead on subjective signs and symptoms, such that there is a "translational gap" between research findings and clinical practice. This gap arises from: a) a lack of integrative theoretical models which provide a basis for understanding links between gene-brain-behavior mechanisms and clinical entities; b) the reliance on studying one measure at a time so that linkages between markers are their specificity are not established; and c) the lack of a definitive understanding of what constitutes normative function. Here, we draw on a standardized methodology for acquiring multiple sources of genomic, brain and behavioral data in the same subjects, to propose candidate markers of selected psychiatric disorders: depression, post-traumatic stress disorder, schizophrenia, attention-deficit/hyperactivity disorder and dementia disorders. This methodology has been used to establish a standardized international database which provides a comprehensive framework and the basis for testing hypotheses derived from an integrative theoretical model of the brain. Using this normative base, we present preliminary findings for a number of disorders in relation to the proposed markers. Establishing these objective markers will be the first step towards determining their sensitivity, specificity and treatment prediction in individual patients.Keywords:Integrative neurosciencemarkersgeneticgenomicneuroimagingEEG/ERPsMRIfMRI autonomicgeneral and social cognitionpsychiatric disorders References R. Adolphs, Curr. Opin. Neurobiol. 12, 169 (2002). Crossref, Medline, ISI, Google ScholarN. T. Aggarwalet al., Neurocase 11, 3 (2005). Crossref, Medline, ISI, Google ScholarL. M. Allanet al., Dement. Geriatr. Cogn. 19, 140 (2005). Crossref, Medline, ISI, Google ScholarJ. L. Armonyet al., Am. J. Psych. 162, 1961 (2005). Crossref, Medline, ISI, Google ScholarJ. Attiaset al., Biol. Psych. 40, 373 (1996). Crossref, Medline, ISI, Google ScholarM. P. Austin, P. Mitchell and G. M. Goodwin, Brit. J. Psych. 178, 200 (2001). Crossref, ISI, Google ScholarL. Backmanet al., J. Intern. Med. 256, 195 (2004). Crossref, Medline, ISI, Google ScholarR. A. Barkley, Ment. Retard. Dev. D R. 5, 177 (1999). Crossref, ISI, Google ScholarR. J. Barry, Int. J. Psychophysiol. 62, 353 (2006). Crossref, Medline, ISI, Google ScholarL. C. Baxteret al., J. Alzheimers. Dis. 9, 253 (2006). Crossref, Medline, ISI, Google ScholarA. Becharaet al., Science 269, 1115 (1995). Crossref, Medline, ISI, Google ScholarD. Begi, L. Hotujac and N. Joki-Begi, Int. J. Psychophysiol. 40, 167 (2001). Crossref, Medline, ISI, Google ScholarA. K. Bergeret al., Neurology 53, 1998 (1999). Crossref, Medline, ISI, Google ScholarD. Blackeret al., Nat. Genet. 19, 357 (1998). Crossref, Medline, ISI, Google ScholarK. Blennow, M. De Leon and H. Zetterberg, Lancet 368, 387 (2006). Crossref, Medline, ISI, Google ScholarS. Y. Bookheimeret al., N. Engl. J. Med. 343, 450 (2000). Crossref, Medline, ISI, Google ScholarN. Borgeret al., J. Abnorm. Child. Psych. 27, 25 (1999). Crossref, Medline, ISI, Google ScholarD. L. Braff, M. A. Geyer and N. R. Swerdlow, Psychopharmacology 156, 234 (2001). Crossref, Medline, ISI, Google ScholarJ. D. Bremneret al., Biol. Psych. 45, 806 (1999). Crossref, Medline, ISI, Google ScholarK. J. Brownet al., Psychol. Med. 30, 1443 (2000). Crossref, Medline, ISI, Google ScholarK. J. Brownet al., Clin. Neurophysiol 113, 1754 (2002). Crossref, Medline, ISI, Google ScholarR. A. Bryantet al., Biol. Psych. 58, 111 (2005). Crossref, Medline, ISI, Google ScholarR. A. Bryant and A. G. Harvey, J. Abnorm. Psych. 104, 537 (1995). Crossref, Medline, ISI, Google Scholar Bryant R. A., Kemp A. H., Felmingham K., Liddell B. J., Olivieri G., Peduto A., Gordon E., Williams L. M., Enhanced amygdala and medial prefrontal activation during nonconscious processing of fear in posttraumatic stress disorder: An fMRI study (under review) . Google ScholarS. Carmonaet al., Neurosci. Lett. 389, 88 (2005). Crossref, Medline, ISI, Google ScholarR. M. Carneyet al., Circulation 104, 2024 (2001). Crossref, Medline, ISI, Google ScholarA. Caspiet al., Science 301, 386 (2003). Crossref, Medline, ISI, Google ScholarK. A. Celoneet al., J. Neurosci. 26, 10222 (2006). Crossref, Medline, ISI, Google ScholarP. Chenet al., Arch. Gen. Psych. 58, 853 (2001). Crossref, Medline, ISI, Google ScholarG. Chetelat and J.-C. Baron, NeuroImage 18, 525 (2003). Crossref, Medline, ISI, Google ScholarC. R. Clarket al., Hum. Brain. Mapp. 9, 42 (2000). Crossref, Medline, ISI, Google ScholarC. R. Clarket al., Biol. Psych. 53, 474 (2003). Crossref, Medline, ISI, Google ScholarH. Cohenet al., Biol. Psych. 41, 627 (1997). Crossref, Medline, ISI, Google ScholarE. Comoliet al., Nat. Neurosci. 6, 974 (2003). Crossref, Medline, ISI, Google ScholarE. H. Corderet al., Science 261, 921 (1993). Crossref, Medline, ISI, Google ScholarP. T. Costa and R. R. McCrae, Psychol. Assessment 4, 5 (1992). Crossref, Google Scholar A. R. Damasio , Descartes' Error. Emotion, Reason and the Human Brain ( Grosset , New York, Putnam , 1994 ) . Google ScholarA. R. Damasio, D. Tranel and H. R. Damasio, Behav. Brain. Res. 41, 81 (1990). Crossref, Medline, ISI, Google ScholarP. Daset al., Schizophr. Res. 90, 284 (2007). Crossref, Medline, ISI, Google ScholarR. J. Davidson and W. Irwin, Trends. in. Cogn. Sci. 3, 11 (1999). Crossref, Medline, ISI, Google ScholarR. J. Davidson and A. J. Tomarken, Handbook of Neuropsychol 3, eds. F. Boller and J. Grafman (Elsevier, Amsterdam, 1989) pp. 419–441. Google ScholarM. Davis and P. J. Whalen, Mol. Psych. 6, 13 (2001). Crossref, Medline, ISI, Google ScholarM. E. Dawson and K. H. Nuechterlein, Schizophr. Bull. 10, 204 (1984). Crossref, Medline, ISI, Google ScholarM. E. Dawsonet al., Arch. Gen. Psych. 51, 813 (1994). Crossref, Medline, ISI, Google ScholarJ. F. de Jongheet al., Int. J. Geriatr. Psych. 18, 748 (2003). Crossref, Medline, ISI, Google ScholarP. Dean, P. Redgrave and G. W. Westby, Trends Neurosci. 12, 137 (1989). Crossref, Medline, ISI, Google ScholarB. C. Dickersonet al., Neurology 65, 404 (2005). Crossref, Medline, ISI, Google ScholarM. A. Diego, T. Field and M. Hernandez-Reif, Depress. Anxiety 13, 32 (2001). Crossref, Medline, ISI, Google ScholarW. C. Drevets, Curr. Opin. Neurobiol. 11, 240 (2001). Crossref, Medline, ISI, Google ScholarW. C. Drevets, Biol. Psych. 48, 813 (2000). Crossref, Medline, ISI, Google ScholarW. C. Drevetset al., Nature 386, 824 (1997). Crossref, Medline, ISI, Google ScholarS. Durstonet al., Mol. Psychiatr. 10, 678 (2005). Crossref, Medline, ISI, Google ScholarS. V. Faraoneet al., Biol. Psych. 57, 1313 (2005). Crossref, Medline, ISI, Google ScholarT. F. D. Farrowet al., Biol. Psych. 58, 713 (2005). Crossref, Medline, ISI, Google ScholarK. L. Felminghamet al., Psychiat. Res. 109, 171 (2002). Crossref, Medline, ISI, Google ScholarD. Fernandez-Duque and S. E. Black, Neuropsychol. 20, 133 (2006). Crossref, ISI, Google ScholarD. Fitzgeraldet al., Aust. NZ J. Psych. 38, 501 (2004). Crossref, Medline, ISI, Google ScholarP. Fossati, A. Radtchenko and P. Boyer, Eur. Neuropsychopharm. S503 (2004). Medline, Google ScholarN. C. Foxet al., Brain 121(), 1631 (1998). Crossref, Medline, ISI, Google ScholarC. Galletlyet al., J. Trauma. Stress 14, 295 (2001). Crossref, Medline, ISI, Google ScholarB. N. Gangadhararet al., J. Aff. Disorders 28, 57 (1993). Crossref, Medline, ISI, Google ScholarJ. M. Gattet al., J. Integr. Neurosci. 6(1), 75 (2007). Link, Google Scholar Gatt J. M., Kuan S., Dobson-Stone C., Paul R. H., Joffe R. T., Kemp A., Gordon E., Schofield P. R., Williams L. M., Alpha band neural activity mediates the role of the BDNF Val66Met polymorphism in risk for depressive features (under review) . Google ScholarS. Gauthieret al., Lancet 367, 1262 (2006). Crossref, Medline, ISI, Google ScholarA. Gilboaet al., Biol. Psych. 55, 263 (2004). Crossref, Medline, ISI, Google Scholar E. Gordon , Personalized. Medicine. . Medline, Google ScholarE. Gordon, Neuropsychopharmacology 28, S2 (2003). Crossref, Medline, Google Scholar E. Gordon , Integrative Neuroscience: Bringing Together Biological, Psychological and Clinical Models of the Human Brain ( Harwood Academic Publishers , Amsterdam , 2000 ) . Crossref, Google ScholarE. Gordonet al., Clin. EEG. and. Neurosci. 36, 64 (2005). Crossref, Medline, ISI, Google ScholarI. I. Gottesman and T. D. Gould, Am. J. Psych. 160, 636 (2003). Crossref, Medline, ISI, Google ScholarC. L. Gradyet al., Brain 124, 739 (2001). Crossref, Medline, ISI, Google ScholarP. M. Greenwoodet al., Neuropsychol. 19, 199 (2005). Crossref, ISI, Google ScholarM. Grundmanet al., Arch. Neurol. 61, 59 (2004). Crossref, Medline, ISI, Google ScholarR. M. Guthrie and R. A. Bryant, Am. J. Psych. 162, 283 (2005). Crossref, Medline, ISI, Google ScholarG. Hasleret al., Neuropsychopharm. 29, 1765 (2004). Crossref, Medline, ISI, Google ScholarD. Headet al., Cerebral Cortex 15, 732 (2005). Crossref, Medline, ISI, Google ScholarW. Heller, Neuropsychol. 7, 476 (1993). Crossref, Google ScholarD. F. Hermenset al., J. Integr. Neurosci. 4, 107 (2005). Link, Google ScholarD. F. Hermenset al., Clin. Neurophysiol. 116, 1455 (2005). Crossref, Medline, ISI, Google ScholarD. F. Hermenset al., Pediatr. Neurol. 32, 248 (2005). Crossref, Medline, ISI, Google ScholarD. F. Hermenset al., Int. J. Psychophysiol. 58, 21 (2005). Crossref, Medline, ISI, Google ScholarJ. P. Hwanget al., Neurobiol. Aging. 27, 1834 (2006). Crossref, Medline, ISI, Google ScholarW. G. Iaconoet al., Arch. Gen. Psych. 40, 557 (1983). Crossref, Medline, ISI, Google ScholarJ. Jeong, Clin. Neurophysiol. 115, 1490 (2004). Crossref, Medline, ISI, Google ScholarX. Jianget al., Neuropsychopharm. 30, 1353 (2005). Crossref, Medline, ISI, Google ScholarS. C. Johnsonet al., NeuroImage 11, 179 (2000). Crossref, Medline, ISI, Google ScholarT. Kato, D. Knopman and H. Liu, Neurology 57, 812 (2001). Crossref, Medline, ISI, Google ScholarH. Kawasakiet al., Nat. Neurosci. 4, 15 (2001). Crossref, Medline, ISI, Google ScholarH. A. Keageet al., J. Integr. Neurosci. 5, 139 (2006). Link, Google Scholar A. H. Kemp et al. , Psychiatry Research: Neuroimaging . Google ScholarA. H. Kempet al., J. Integr. Neurosci. 5, 89 (2006). Link, Google ScholarA. H. Kempet al., J. Integr. Neurosci. 4, 95 (2005). Link, Google ScholarK. S. Kendleret al., Arch. Gen. Psych. 62, 529 (2005). Crossref, Medline, ISI, Google Scholar P. J. Lang , Emotions: Essays on Emotion Theory , eds. S. VanGoozen , N. E. Van de Poll and J. A. Sergeant ( Hillsdale , Erlbaum, NJ , 1994 ) . Google ScholarJ. E. LeDoux, Ann. Rev. Neurosci. 23, 155 (2000). Crossref, Medline, ISI, Google ScholarH. J. Leeet al., Depress Anxiety 21, 135 (2005). Crossref, Medline, ISI, Google ScholarK. H. Leeet al., Brain. Res. Rev. 41, 57 (2003). Crossref, Medline, ISI, Google ScholarB. J. Liddellet al., J. Integr. Neurosci. 6(1), 141 (2007). Link, Google ScholarC. L. Limet al., Biol. Psych. 45, 127 (1999). Crossref, Medline, ISI, Google ScholarM. Lindauet al., Dement. Geriatr. Cogn. 15, 106 (2003). Crossref, Medline, ISI, Google ScholarR. Linkeet al., J. Comp. Neurol. 403, 158 (1999). Crossref, Medline, ISI, Google ScholarC. A. Mangina and E. N. Sokolov, Int. J. Psychophysiol. 60, 203 (2006). Crossref, Medline, ISI, Google ScholarJ. C. Masdeu, J. L. Zubieta and J. Arbizu, J. Neuro. Sci. 236, 55 (2005). Crossref, Medline, ISI, Google ScholarH. S. Mayberget al., Neuroreport 8, 1057 (1997). Crossref, Medline, ISI, Google ScholarH. S. Mayberget al., Am. J. Psych. 156, 675 (1999). Medline, ISI, Google ScholarJ.-P. Mialet, H. G. Pope and D. Yurgelun-Todd, Psychol. Med. 26, 1009 (1996). Crossref, Medline, ISI, Google ScholarP. J. Modrego, Curr. Alzheimer. Res. 3, 161 (2006). Crossref, Medline, Google ScholarY. Narainet al., J. Med. Genet. 37, 695 (2000). Crossref, Medline, ISI, Google ScholarC. B. Nemeroff and M. J. Owens, Nature Neuroscience S5, 1068 (2002). Google ScholarJ. Olds, The Am. Psychol. 24, 114 (1999). Crossref, Medline, ISI, Google ScholarS. P. Orret al., Arch. Gen. Psych. 60, 283 (2003). Crossref, Medline, ISI, Google ScholarF. Panzaet al., Mechanisms of Aging and Development 127, 36 (2006). Crossref, Medline, ISI, Google ScholarM. A. Pericak-Vanceet al., Experimental Gerontology 35, 1343 (2000). Crossref, Medline, ISI, Google ScholarR. K. Pitmanet al., New York Academy of Sciences 1071, 242 (2006). Crossref, Medline, ISI, Google ScholarM. I. Posner and S. E. Petersen, Annual Review of Neuroscience 13, 25 (1990). Crossref, Medline, ISI, Google ScholarS. L. Rauch, L. M. Shin and E. A. Phelps, Biol. Psych. 60, 376 (2006). Crossref, Medline, ISI, Google ScholarS. L. Rauchet al., Neuroreport 14, 913 (2003). Crossref, Medline, ISI, Google ScholarS. L. Rauchet al., Biol. Psych. 47, 769 (2000). Crossref, Medline, ISI, Google ScholarC. Rennie, P. A. Robinson and J. J. Wright, Biol. Cyb. 86, 457 (2002). Crossref, Medline, ISI, Google ScholarC. A. Riccioet al., Arch. Clin. Neuropsychol. 17, 235 (2002). Crossref, Medline, ISI, Google ScholarP. A. Robinsonet al., Neuropsychopharm. 28, 74 (2003). Crossref, ISI, Google ScholarM. A. Rogerset al., Neurosci. Res. 50, 1 (2004). Crossref, Medline, ISI, Google ScholarK. Rubiaet al., Am. J. Psych. 156, 891 (1999). Crossref, Medline, ISI, Google ScholarG. N. Savla and B. W. Palmer, Curr. Opin. Psych. 18, 621 (2005). Crossref, ISI, Google ScholarG. D. Schellenberg, I. D'Souza and P. Poorkaj, Curr. Psych. Reports 2, 158 (2000). Crossref, Medline, Google Scholar Schofield P, Williams LM, Paul RH, Gatt JM, Brown KJ, Luty A, Cooper N, Grieve SM, Dobson-Stone C, Kuan SA, Gordon E, Disturbances in task-relevant information processing associated with the brain-derived neurotrophic factor Val66Met polymorphism: Evidence from cognition, the P300 endophenotype and neuroimaging, NeuroImage (under review) . Google ScholarA. Y. Shalevet al., Am. J. Psych. 157, 255 (2000). Crossref, Medline, ISI, Google ScholarS. M. Silversteinet al., Psychiat. Quart. 69, 169 (1998). Crossref, Medline, ISI, Google ScholarE. N. Sokolov and W. Boucsein, Integr. Physiol. Behav. Sci. 35, 81 (2000). Crossref, Medline, ISI, Google ScholarP. K. Stein and R. E. Kleiger, Ann. Rev. Med. 50, 49 (1999). Google ScholarM. P. Symondet al., Am. J. Psych. 162, 459 (2005). Crossref, Medline, ISI, Google ScholarS. J. Teipelet al., J. Neurol. 253, 794 (2006). Crossref, Medline, ISI, Google ScholarP. J. Uhlhaas and W. Singer, Neuron 52, 155 (2006). Crossref, Medline, ISI, Google ScholarK. van der Hieleet al., Neurobiol. Aging. (2006). Google ScholarM. D. Veltmeyeret al., J. Integr. Neurosci. 4, 145 (2005). Link, Google ScholarM. D. Veltmeyeret al., J. Integr. Neurosci. 5, 123 (2006). Link, Google ScholarS. Verteet al., J. Neurosci. Methods 151, 5 (2006). Crossref, Medline, ISI, Google ScholarT. J. Whitfordet al., NeuroImage 32, 511 (2006). Crossref, Medline, ISI, Google ScholarT. J. Whitfordet al., Hum. Brain. Mapp. 9, 1196 (2006). Google ScholarL. M. Williams, J. Integr. Neurosci. 5, 1 (2006). Link, ISI, Google ScholarL. M. Williamset al., Am. J. Psych. 161, 480 (2004). Crossref, Medline, ISI, Google ScholarL. M. Williams and E. Gordon, The Neuroscientist (2007). Google ScholarL. M. Williamset al., NeuroImage 29, 347 (2006). Crossref, Medline, ISI, Google ScholarL. M. Williamset al., Psych. Res. 120, 13 (2003). Crossref, Medline, ISI, Google ScholarL. M. Williamset al., NeuroImage 31, 458 (2006). Crossref, Medline, ISI, Google ScholarL. M. Williamset al., NeuroImage 14, 1070 (2001). Crossref, Medline, ISI, Google ScholarV. K. Yeragani, Depress Anxiety 2, 51 (2000). Google ScholarV. K. Yeraganiet al., Biol. Psych. 52, 418 (2002). Crossref, Medline, ISI, Google ScholarV. K. Yeraganiet al., Biol. Psych. 51, 733 (2002). Crossref, Medline, ISI, Google ScholarG. Yong-Lianget al., Brain. Cogn. 43, 215 (2000). Medline, ISI, Google ScholarR. Zulliet al., J. Am. Geriatr. Soc. 53, 2135 (2005). Crossref, Medline, ISI, Google Scholar FiguresReferencesRelatedDetailsCited By 21P50, N100, and P200 Sensory Gating in Panic DisorderLars Thoma, Johannes Rentzsch, Katharina Gaudlitz, Nicole Tänzer and Jürgen Gallinat et al.9 January 2020 | Clinical EEG and Neuroscience, Vol. 51, No. 5Neural and genetic mechanisms of creative potentialZhiting Ren, Wenjing Yang and Jiang Qiu1 Jun 2019 | Current Opinion in Behavioral Sciences, Vol. 27Reduced Sensitivity to Non-Fear-Related Stimulus Changes in Panic DisorderJohannes Rentzsch, Lars Thoma, Katharina Gaudlitz, Nicole Tänzer and Jürgen Gallinat et al.4 April 2019 | Neuropsychobiology, Vol. 78, No. 1Degeneracy: Demystifying and destigmatizing a core concept in systems biologyPaul H. 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