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BIBTEX RIS

Diploflavone, a new flavonoid from Diplotropis ferruginea Benth. (Fabaceae)

2005; Brazilian Chemical Society; Volume: 16; Issue: 6b Linguagem: Inglês

10.1590/s0103-50532005000800027

ISSN

1678-4790

Autores

Jackson Roberto Guedes da Silva Almeida, José Maria Barbosa‐Filho, Analúcia Guedes Silveira Cabral, Maria de Fátima Agra, Emídio Vasconcelos Leitão da Cunha, Marcelo Sobral da Silva, Silène Carneiro do Nascimento, Raimundo Braz‐Filho,

Tópico(s)

Natural product bioactivities and synthesis

Resumo

The chemical examination of Diplotropis ferruginea Benth. resulted in the isolation of a new 3-methoxyflavone, 3-methoxy-6-O-prenyl-6",6"-dimethylchromene-(7,8,2",3")-flavone, to which was given the trivial name diploflavone (1); as well as the known 3,6-dimethoxy-6",6"-dimethylchromene-(7,8,2",3")-flavone (2). The structure of the new compound was established by spectral analyses. Cytotoxic activity of the isolated compounds was tested against the cells NCI-H292 (lung carcinoma), HEp-2 (larynx carcinoma) and KB (oral epidermoid carcinoma). The cells HEp-2 were the most affected by the substances tested.

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