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Clinical presentation and management of drug-induced agranulocytosis

2011; Taylor & Francis; Volume: 4; Issue: 2 Linguagem: Inglês

10.1586/ehm.11.12

1747-4086

Emmanuel Andrès, Jacques Zimmer, Mustapha Mecili, Thierry Weitten, Martine Alt, Frédéric Maloisel,

Neutropenia and Cancer Infections

In this article, we report and discuss the clinical presentation and management of idiosyncratic drug-induced agranulocytosis (neutrophil count 65 years), septicemia or shock, metabolic disorders such as renal failure and a neutrophil count below 0.1 × 10(9)/l are currently consensually accepted as poor prognostic factors. In this potentially life-threatening disorder, modern management with broad-spectrum antibiotics and hematopoietic growth factors (particularly granulocyte colony-stimulating factor) is likely to improve prognosis. Thus, with appropriate management, the mortality rate from idiosyncratic drug-induced agranulocytosis is currently approximately 5%.