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BIBTEX RIS

Proteinase Inhibitors: A Promising Drug Class for Treating Leishmaniasis

2014; Bentham Science Publishers; Volume: 15; Issue: 12 Linguagem: Inglês

10.2174/1389450115666141016150007

1873-5592

Bernardo Acácio Santini Pereira, Franklin Souza‐Silva, Mariana Silva-Almeida, Raquel Santos-de-Souza, Luiz Fernando Ganassali de Oliveira Júnior, Michelle Lopes Ribeiro-Guimarães, Carlos Roberto Alves,

Trypanosoma species research and implications

This review presents and discusses the current status and perspectives of leishmaniasis treatment, with a special focus on the use of proteinase inhibitors. The history of treatment development, the first- and second-choice modern drugs and the advantages and disadvantages of using proteinases inhibitors as leishmanicidal treatments are presented and discussed. The reports gathered herein confirm the potential usefulness of proteinases inhibitors as an alternative or complement to the current leishmaniasis treatments. They also support the hypothesis that a combined treatment with multiple proteinase inhibitors may be efficient against Leishmania infections in vertebrate hosts.