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A Nanogel for Ratiometric Fluorescent Sensing of Intracellular pH Values

2010; Wiley; Volume: 49; Issue: 25 Linguagem: Inglês

10.1002/anie.200906926

1521-3773

Hongshang Peng, Judith A. Stolwijk, Lining Sun, Joachim Wegener, Otto S. Wolfbeis,

Supramolecular Self-Assembly in Materials

A ratiometric fluorescent nanogel can sense pH over a range that is applicable to physiological studies. It can be easily prepared and made pH-responsive by addition of a pH probe and a FRET system that utilizes the gel to hold dyes in close proximity (see picture; overlay of coumarin dye and Nile Red fluorescence in kidney cells).