Produção Nacional
Revisado por pares
Trigeminal Nerve Stimulation (TNS) for Generalized Anxiety Disorder: A Case Study
2015; Elsevier BV; Volume: 8; Issue: 3 Linguagem: Inglês
10.1016/j.brs.2014.12.009
ISSN1935-861X
AutoresAlisson Paulino Trevizol, Pedro Shiozawa, Isa Albuquerque Sato, Elie Leal de Barros Calfat, Rodrigo Lancelote Alberto, Ian A. Cook, Heloisa H. Medeiros, Quirino Cordeiro,
Tópico(s)Transcranial Magnetic Stimulation Studies
ResumoGeneralized anxiety disorder (GAD) [ [1] Kessler R.C. Chiu W.T. Demler O. et al. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005; 62: 617-627 Crossref PubMed Scopus (8288) Google Scholar ] presents with an overall prevalence of 4–7%. Although available treatment is effective in many patients, treatment-resistance and low adherence due to adverse effects are some issues that compromise optimal treatment. In fact about 25% of patients reportedly fail to respond to treatment [ 2 Ballenger J.C. Panic disorder in primary care and general medicine. in: Rosenbaum J.F. Pollack M.H. Panic disorder and its treatment. Dekker Inc, New York1998: 1-36 Google Scholar , 3 Craske M.G. Edlund M.J. Sullivan G. et al. Perceived unmet need for mental health and barriers to among care patients with panic disorder. Psychiatr Serv. 2005; 56: 988-994 Crossref PubMed Scopus (50) Google Scholar ]. Brain stimulation techniques have shown promising results for anxiety symptoms [ 4 Zwanzger P. Fallgatter A.J. Zavorotnyy M. Padberg F. Anxiolytic effects of transcranial magnetic stimulation—an alternative treatment option in anxiety disorders?. J Neural Transm. 2009; 116: 767-775 Crossref PubMed Scopus (58) Google Scholar , 5 Shiozawa P. Leiva A.P. Castro C.D. et al. Transcranial Direct Current Stimulation (tDCS) for generalized anxiety disorder: a case study. Biol Psychiatry. 2014 Jun 1; 75: e17-e18 Abstract Full Text Full Text PDF PubMed Scopus (57) Google Scholar ]. Following previous results of different neuromodulation strategies, Trigeminal Nerve Stimulation (TNS) may also be able to exert anxiolytic effects in the clinical scenario. TNS is a non-invasive strategy based on the application of an low-energy electric signal to stimulate branches of the trigeminal nerve with further propagation of the stimuli toward brain areas related to mood and anxiety symptoms [ [6] Shiozawa P. Duailibi M.S. da Silva M.E. Cordeiro Q. Trigeminal nerve stimulation (TNS) protocol for treating major depression: an open-label proof-of-concept trial. Epilepsy Behav. 2014 Aug 19; 39C: 6-9 Abstract Full Text Full Text PDF Scopus (23) Google Scholar ]. TNS has been reported to reduce anxiety symptoms in patients with a primary diagnosis of major depression [ [7] Cook I.A. Schrader L.M. Degiorgio C.M. Miller P.R. Maremont E.R. Leuchter A.F. Trigeminal nerve stimulation in major depressive disorder: acute outcomes in an open pilot study. Epilepsy Behav. 2013 Aug; 28: 221-226 Abstract Full Text Full Text PDF PubMed Scopus (56) Google Scholar ] but has not been previously examined as a treatment for primary GAD.
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