3-Chloromethylpyridyl bipyridine fac-tricarbonyl rhenium: a thiol-reactive luminophore for fluorescence microscopy accumulates in mitochondria
2008; Royal Society of Chemistry; Volume: 32; Issue: 7 Linguagem: Inglês
10.1039/b802215a
ISSN1369-9261
AutoresAngelo J. Amoroso, Richard J. Arthur, Michael P. Coogan, J.B. Court, Vanesa Fernández‐Moreira, Anthony J. Hayes, David Lloyd, Coralie Millet, Simon J. A. Pope,
Tópico(s)Click Chemistry and Applications
ResumoThe 3-chloromethylpyridyl bipyridine fac tricarbonyl rhenium cation is a thiol-reactive luminescent agent with a long luminescence lifetime and large Stokes shift that is demonstrated by co-localisation studies to accumulate in mitochondria. This represents the first application of a 3MLCT luminescent agent for the specific targeting of a biological entity in imaging.
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