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Mild and regioselective iodination of electron-rich aromatics with N -iodosuccinimide and catalytic trifluoroacetic acid

2002; Elsevier BV; Volume: 43; Issue: 29 Linguagem: Inglês

10.1016/s0040-4039(02)01010-9

1873-3581

Anne‐Sophie Castanet, Françoise Colobert, Pierre‐Emmanuel Broutin,

Synthesis and Biological Evaluation

A variety of aromatics compounds substituted with methoxy or methyl groups were regioselectively iodinated with N-iodosuccinimide and catalytic trifluoroacetic acid with excellent yields under mild conditions and short reaction times.