HEMATOLYMPHOID MALIGNANCIES DIAGNOSED AT THE TIME OF RADICAL PROSTATECTOMY
1997; Lippincott Williams & Wilkins; Volume: 158; Issue: 4 Linguagem: Inglês
10.1016/s0022-5347(01)64242-3
ISSN1527-3792
AutoresMartha K. Terris, John Hausdorff, Fuad S. Freiha,
Tópico(s)Viral-associated cancers and disorders
ResumoNo AccessJournal of UrologyClinical Urology: Original Articles1 Oct 1997HEMATOLYMPHOID MALIGNANCIES DIAGNOSED AT THE TIME OF RADICAL PROSTATECTOMY Martha K. Terris, John Hausdorff, and Fuad S. Freiha Martha K. TerrisMartha K. Terris , John HausdorffJohn Hausdorff , and Fuad S. FreihaFuad S. Freiha View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)64242-3AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The clinical impact of hematolymphoid malignancies discovered during radical prostatectomy has not been previously defined to our knowledge. Materials and Methods: From October 1988 to September 1995, 1,092 patients underwent radical retropubic prostatectomy. Results: Of 1,092 radical prostatectomy specimens, 13 (1.2%) were found to have hematologic malignancies involving the prostate and/or lymph nodes sampled during concomitant pelvic lymph node dissection. The malignancies detected included Hodgkin's disease (3) and hairy cell leukemia (1), which required further therapy. However, 9 of the 13 patients (62%) demonstrated either chronic lymphocytic leukemia (3) or low grade, small lymphocytic lymphoma (6), which requires symptomatic treatment only. The transrectal ultrasound guided prostate biopsies revealed suspicious lymphocytic infiltrate in addition to prostatic adenocarcinoma in 2 of the 13 patients (15%). Conclusions: The majority of hematologic malignancies discovered at radical prostatectomy do not require further treatment and should not delay treatment of prostatic adenocarcinoma. References 1 Donohue R.E.: Second malignancies in adenocarcinoma of the prostate. Sixth International Prostate Cancer Update, Beaver Creek, Colorado, February 3, 1996. Google Scholar 2 Donohue R.E.: Causes of death in a radical prostatectomy series. Sixth International Prostate Cancer Update, Beaver Creek, Colorado, February 3, 1996. Google Scholar 3 : Lymphocytic lymphomas.. In: Cancer: Principles and Practice of Oncology. Edited by . Philadelphia: J. B. Lippincott Company1993: 1859. chapt. 52. Google Scholar 4 : Chronic leukemias.. In: Cancer: Principles and Practice of Oncology. Edited by . Philadelphia: J. B. Lippincott Company1993: 1965. chapt. 55. Google Scholar 5 : Chronic lymphoctic leukemia.. In: Hematology: Basic Principles and Practice. Edited by . New York: Churchill Livingstone, Inc.1995: 1308. part VI, chapt. 83. Google Scholar 6 : Clinical staging of chronic lymphocytic leukemia.. Blood1975; 46: 219. Google Scholar 7 : Chronic lymphocytic leukaemia: prognostic factors and natural history.. Baillieres Clin. Haematol.1993; 6: 849. Google Scholar 8 : Natural history of chronic lymphocytic leukaemia: on the progression and prognosis of early clinical stages.. Nouv. Rev. Fr. Hematol.1988; 30: 359. Google Scholar 9 Natural history of stage A chronic lymphocytic leukemia untreated patients. French Cooperative Group on Chronic Lymphocytic Leukemia.. Brit. J. Haematol.1990; 76: 45. Google Scholar 10 : Non-Hodgkin's lymphomas: pathologic features and clinical correlations.. In: Hematology: Basic Principles and Practice. Edited by . New York: Churchill Livingstone, Inc.1995: 1247. part VI, chapt. 80. Google Scholar 11 : Natural history of and therapy for the indolent non-Hodgkin's lymphomas.. Sem. Oncol.1993; 20: 75. Google Scholar 12 : The identification of discrete prognostic groups in low grade non-Hodgkin's lymphoma. The Scotland and Newcastle Lymphoma Group Therapy Working Party.. Ann. Oncol.1991; 2: 655. Google Scholar 13 : Hodgkin's disease.. In: Cancer: Principles and Practice of Oncology. Edited by . Philadelphia: J. B. Lippincott Company1993: 1819. chapt. 51. Google Scholar 14 : Hogdkin's disease: clinical manifestations, staging and therapy.. In: Hematology: Basic Principles and Practice. Edited by . New York: Churchill Livingstone, Inc.1995: 1226. part VI, chapt. 79. Google Scholar 15 : The management of stage I-II Hodgkin's disease with irradiation alone or combined modality therapy: the Stanford experience.. Blood1982; 59: 455. Google Scholar 16 : Radiation therapy in clinical stage I and II Hodgkin's disease.. Eur. J. Cancer1992; 28A: 1841. Google Scholar 17 : Twenty years of MOPP chemotherapy for Hodgkin's disease.. J. Clin. Oncol.1986; 4: 1295. Google Scholar 18 : Combined modality therapy for advanced Hodgkin's disease: 15 year follow up data.. J. Clin. Oncol.1988; 6: 603. Google Scholar 19 : Hairy cell leukemia.. In: Hematology: Basic Principles and Practice. Edited by . New York: Churchill Livingstone, Inc.1995: 1322. part VI, chapt. 84. Google Scholar 20 : Acute leukemia.. In: Cancer: Principles and Practice of Oncology. Edited by . Philadelphia: J. B. Lippincott Company1993: 1938. chapt. 54. Google Scholar 21 : False-positive serum prostate-specific antigen values in patient with non-Hodgkin's lymphoma of the kidney.. Urology1995; 45: 875. Google Scholar 22 : Life-threatening leukopenia following flutamide during downstaging of a PSA false-positive lymphoma invading the prostate.. Read at annual meeting of Western Section. San Diego, California: American Urological AssociationJuly 28, 1996. Google Scholar 23 : Severe reversible neutropenia following treatment of prostate cancer with flutamide.. J. Urol.1994; 151: 1353. Abstract, Google Scholar From the Department of Urology and Division of Oncology, Stanford University Medical Center, Stanford and Sections of Urology and Oncology, Palo Alto Veterans Affairs Medical Center, Palo Alto, California.© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 158Issue 4October 1997Page: 1457-1459 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.MetricsAuthor Information Martha K. Terris More articles by this author John Hausdorff More articles by this author Fuad S. Freiha More articles by this author Expand All Advertisement PDF downloadLoading ...
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