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Effect of bumetanide on the positive endocochlear dc potential of the cat

1976; Elsevier BV; Volume: 38; Issue: 1 Linguagem: Inglês

10.1016/0041-008x(76)90167-8

1096-0333

R. Don Brown,

Animal Nutrition and Physiology

Twenty-seven cats were recorded from the scala media of the cochlea in order to evaluate the reduction in the positive endocochlear dc potential (EP) produced by iv bumetanide and to compare these changes to the bumetanide-induced N1 depression observed previously. A linear relationship does exist between the dose of bumetanide administered and the resultant mV reduction of the EP. The equation for the regression line of this dose-response to bumetanide is y (maximal reduction of EP) = 259.5 + 92.8 × (log mmol/kg iv bumetanide). The maximal reduction of EP occurring within 1 min after the larger doses of bumetanide correlates well with changes in N1 previously observed after similar doses. When multiple linear regression analysis is performed, the amount of N1 depression produced by a particular dose of bumetanide is found to be linearly related to the amount of EP reduction produced by that dose of bumetanide. These data indicate that the acute ototoxicity produced by this "loop" diuretic is due to its effect on EP.