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In vitro Evaluation of the Pollen Extract Cernitin T‐60, in the Regulation of Prostate Cell Growth

1990; Wiley; Volume: 66; Issue: 4 Linguagem: Inglês

10.1111/j.1464-410x.1990.tb14961.x

1365-2176

F.K. Habib, Margaret Ross, A Buck, L. EBELING, Ari Lewenstein,

Toxin Mechanisms and Immunotoxins

Nine human-derived cancer and non-cancer continuous cell lines were employed to evaluate the relative in vitro activity of the pollen extract, Cernitin T-60. Responses of the cell lines to the drug were assessed by measuring growth and cell survival as determined by cell count. The results demonstrated that of the 9 continuous cell lines tested, only those derived from the human prostate were growth inhibited by the pollen extract, whereas the non-prostate derived cells exhibited variable degrees of resistance to the T-60. The selectivity of the drug for the prostate cell lines was even more pronounced in the hormone-independent models, suggesting that there might be a place for the pollen extract in the control of abnormal growth in hormone-insensitive cells.