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Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis

2005; Elsevier BV; Volume: 161; Issue: 1-2 Linguagem: Inglês

10.1016/j.jneuroim.2004.12.006

1872-8421

Shingo Kato, Yoshikazu Tsuzuki, Ryota Hokari, Yoshikiyo Okada, Jun‐ichi Miyazaki, Koji Matsuzaki, Atsuhiro Iwai, Atsushi Kawaguchi, Shigeaki Nagao, Kazuro Itoh, Hidekazu Suzuki, Toshitaka Nabeshima, Soichiro Miura,

Cardiovascular, Neuropeptides, and Oxidative Stress Research

Nociceptin/orphanin (Noc/oFQ), endogenous agonist for nociceptin receptor (NOR), is thought to be a stimulator of neurogenic inflammation. We investigated the possible role of Noc/oFQ in the development of colitis using NOR-deficient mice treated with dextran sulfate sodium (DSS). Colitis was significantly improved in NOR-deficient mice against wild-type mice. Expression level of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and infiltrating cells also significantly decreased in NOR-deficient mice against wild-type mice. Nociceptin expression increased in wild-type mice after DSS treatment. These results suggest stimulation by Noc/oFQ deteriorates colonic inflammation via up-regulation of adhesion molecule.