Portal de Periódicos da CAPES

Versatility of the Endoplasmic Reticulum Protein Folding Factory

2005; Taylor & Francis; Volume: 40; Issue: 4 Linguagem: Inglês

10.1080/10409230591008161

1549-7798

Eelco van Anken, Ineke Braakman,

Glycosylation and Glycoproteins Research

The endoplasmic reticulum (ER) is dedicated to import, folding and assembly of all proteins that travel along or reside in the secretory pathway of eukaryotic cells. Folding in the ER is special. For instance, newly synthesized proteins are N-glycosylated and by default form disulfide bonds in the ER, but not elsewhere in the cell. In this review, we discuss which features distinguish the ER as an efficient folding factory, how the ER monitors its output and how it disposes of folding failures.