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Prognoses and improvement for head and neck cancers diagnosed in Europe in early 2000s: The EUROCARE-5 population-based study

2015; Elsevier BV; Volume: 51; Issue: 15 Linguagem: Inglês

10.1016/j.ejca.2015.07.043

1879-0852

Gemma Gatta, Laura Botta, María‐José Sánchez, Lesley Anderson, Daniela Pierannunzio, Lisa Licitra, Monika Hackl, N. Zielonke, Willi Oberaigner, E. Van Eycken, K. Henau, Z. Valerianova, Nadya Dimitrova, Mario Šekerija, Miroslav Zvolský, Ladislav Dušek, Hans H. Storm, Gerda Engholm, Margit Mägi, Tiiu Aareleid, Nea Malila, Karri Seppä, Michel Velten, X. Troussard, Véronique Bouvier, Guy Launoy, A.V. Guizard, Jean Faivre, Anne‐Marie Bouvier, P. Arveux, Marc Maynadié, Anne‐Sophie Woronoff, Michel Robaszkiewicz, Isabelle Baldi, Alain Monnereau, Brigitte Trétarre, Nadine Bossard, Aurélien Belot, Marc Colonna, F. Molinié, S. Bara, C. Schvartz, B. Lapôtre‐Ledoux, Pascale Grosclaude, M. Meyer, Roland Stabenow, Sabine Luttmann, Andrea Eberle, Hermann Brenner, Alice Nennecke, Jutta Engel, G. Schubert-Fritschle, Joachim Kieschke, Jan Heidrich, Bernd Holleczek, Alexander Katalinic, Jón G. Jónasson, Laufey Tryggvadóttír, Harry Comber, Guido Mazzoleni, A. Bulatko, Carlotta Buzzoni, Adriano Giacomin, A. Mazzei A. Sutera Sardo, Stefano Ferretti, Emanuele Crocetti, Gianfranco Manneschi, Gemma Gatta, Milena Sant, H. Amash, C. Amati, Paolo Baili, Franco Berrino, S. Bonfarnuzzo, Laura Botta, F. Di Salvo, Roberto Foschi, C. Margutti, E. Meneghini, Pamela Minicozzi, Annalisa Trama, Diego Serraino, Antonella Zucchetto, Roberta De Angelis, M. Caldora, Riccardo Capocaccia, E. Carrani, Silvia Francisci, Sandra Mallone, Daniela Pierannunzio, P. Roazzi, Silvia Rossi, Mariano Santaquilani, Andrea Tavilla, Fabio Pannozzo, M. Natali, L Bonelli, Marina Vercelli, Valerio Gennaro, Paolo Ricci, M. Autelitano, G. Randi, Maurizio Ponz de Leòn, C. Marchesi, Claudia Cirilli, Mario Fusco, M.F. Vitale, M. Usala, A. Traina, Maurizio Zarcone, Francesco Vitale, Rosanna Cusimano, Maria Michiara, ­Rosario ­Tumino, Paolo Giorgi Rossi, Massimo Vicentini, Fabio Falcini, Antonio Iannelli, O. Sechi, R. Cesaraccio, Silvano Piffer, A Madeddu, F. Tisano, S. Maspero, A.C. Fanetti, Roberto Zanetti, Stefano Rosso, P. Candela, T. Scuderi, Fabrizio Stracci, Andrea Rocca, Giovanna Tagliabue, Paolo Contiero, Angelo Paolo Dei Tos, Sandro Tognazzo, Santa Pildava, Giedrė Smailytė, Neville Calleja, R. Micallef, Tom Børge Johannesen, Jadwiga Rachtan, Stanisław Góźdż, Ryszard Mężyk, Jerzy Błaszczyk, Kamila Kępska, Magdalena Bielska‐Lasota, G. Forjaz de Lacerda, María José Bento, Luís Antunes, A. Miranda, A. Mayer-da-Silva, Florian Nicula, Daniela Coza, C. Safaei Diba, Maja Primic‐Žakelj, E. Almar, Antonio Navareño Mateos, M. Errezola, Nerea Larrañaga, A. Torrella-Ramos, J.M. Díaz García, A.I. Marcos-Navarro, Rafael Marcos‐Gragera, L. Vilardell, María‐José Sánchez, Esther Molina‐Montes, Carmen Navarro, María‐Dolores Chirlaque, C. Moreno-Iribas, Eva Ardanáz, Jaume Galcerán, M. Carulla, Mats Lambe, S. Khan, Seyed Mohsen Mousavi, Christine Bouchardy, M. Usel, S.M. Ess, H. Frick, Matthias Lorez, S.M. Ess, C. Herrmann, Andrea Bordoni, Alessandra Spitale, Isabelle Konzelmann, Otto Visser, Boukje A. C. van Dijk, Michel P. Coleman, Claudia Allemani, Bernard Rachet, Julia Verne, N. Easey, Gill Lawrence, Teresa Morán, Jem Rashbass, M. Roche, J. Wilkinson, Anna Gavin, Deirdre Fitzpatrick, David Brewster, Dyfed Huws, Peter D. White, R. Otter,

Cancer Diagnosis and Treatment

Head and neck (H&N) cancers are a heterogeneous group of malignancies, affecting various sites, with different prognoses. The aims of this study are to analyse survival for patients with H&N cancers in relation to tumour location, to assess the change in survival between European countries, and to investigate whether survival improved over time.We analysed about 250,000 H&N cancer cases from 86 cancer registries (CRs). Relative survival (RS) was estimated by sex, age, country and stage. We described survival time trends over 1999-2007, using the period approach. Model based survival estimates of relative excess risks (RERs) of death were also provided by country, after adjusting for sex, age and sub-site.Five-year RS was the poorest for hypopharynx (25%) and the highest for larynx (59%). Outcome was significantly better in female than in male patients. In Europe, age-standardised 5-year survival remained stable from 1999-2001 to 2005-2007 for laryngeal cancer, while it increased for all the other H&N cancers. Five-year age-standardised RS was low in Eastern countries, 47% for larynx and 28% for all the other H&N cancers combined, and high in Ireland and the United Kingdom (UK), and Northern Europe (62% and 46%). Adjustment for sub-site narrowed the difference between countries. Fifty-four percent of patients was diagnosed at advanced stage (regional or metastatic). Five-year RS for localised cases ranged between 42% (hypopharynx) and 74% (larynx).This study shows survival progresses during the study period. However, slightly more than half of patients were diagnosed with regional or metastatic disease at diagnosis. Early diagnosis and timely start of treatment are crucial to reduce the European gap to further improve H&N cancers outcome.