Exercise training in mitochondrial myopathy: A randomized controlled trial
2005; Wiley; Volume: 32; Issue: 3 Linguagem: Inglês
10.1002/mus.20368
ISSN1097-4598
AutoresPilar Cejudo, Juan Bautista, Teodoro Montemayor, Rafael Villagómez, L. Jiménez, Francisco Órtega Ruiz, Yolanda Campos, H Catalina Salinas Sánchez, Joaquı́n Arenas,
Tópico(s)Glycogen Storage Diseases and Myoclonus
ResumoAbstract Patients with mitochondrial myopathies (MM) usually suffer from exercise intolerance due to their impaired oxidative capacity and physical deconditioning. We evaluated the effects of a 12‐week supervised randomized rehabilitation program involving endurance training in patients with MM. Twenty MM patients were assigned to a training or control group. For three nonconsecutive days each week, patients combined cycle exercise at 70% of their peak work rate with three upper‐body weight‐lifting exercises performed at 50% of maximum capacity. Training increased maximal oxygen uptake (28.5%), work output (15.5%), and minute ventilation (40%), endurance performance (62%), walking distance in shuttle walking test (+95 m), and peripheral muscle strength (32%–62%), and improved Nottingham Health Profile scores (21.47%) and clinical symptoms. Control MM patients did not change from baseline. Results show that our exercise program is an adequate training strategy for patients with mitochondrial myopathy. Muscle Nerve, 2005
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