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A Novel Synthesis and Molluscicidal Activity of some Functionally Substituted Pyridine, Pyrido[3,2‐c]pyridazine, and Pyrido[3,2‐c]pyridazino[2′,3′‐a]quinazoline Derivatives

2005; Wiley; Volume: 338; Issue: 7 Linguagem: Inglês

10.1002/ardp.200400938

1521-4184

Fathy M. Abdelrazek, Alaa El‐Din M. Fathy,

Quinazolinone synthesis and applications

Ethyl benzoylacetate reacts with the malononitrile dimer to afford 4-amino-5-benzoyl-2-dicyano methyl-6-hydroxypyridine, which undergoes the coupling reaction with aromatic diazonium salts to afford azo derivatives. These azo derivatives could be cyclized into pyrido[3,2-c]pyridazine and pyrido[3,2-c]pyridazino[2',3'-a]quinazoline derivatives upon reflux in ethanolic NaOH, presumably via their hydrazo tautomers. The molluscicidal activity of these compounds was evaluated.