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“Click and go”: simple and fast folic acid conjugation

2014; Royal Society of Chemistry; Volume: 12; Issue: 20 Linguagem: Inglês

10.1039/c4ob00150h

1477-0539

Alexandre F. Trindade, Raquel F. M. Frade, Ermelinda Maçôas, Cátia A. L. Graça, Catarina A. B. Rodrigues, J. M. G. Martinho, Carlos A. M. Afonso,

Advanced Biosensing Techniques and Applications

A novel approach for conjugation of folic acid is presented allowing for its quantitative conjugation with several types of molecules (fluorescent probes) and materials (polymers and silica) based on strain-promoted alkyne–azide cycloaddition, without the need for expensive chromatographic purifcation.