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Susceptibility of Helicobacter pylori to simethicone and other non-antibiotic drugs

1996; Oxford University Press; Volume: 37; Issue: 1 Linguagem: Inglês

10.1093/jac/37.1.45

1460-2091

R. Ansorg, G. von Recklinghausen, Evelyn Heintschel von Heinegg,

Phytochemistry and Bioactive Compounds

The antifoaming agent simethicone (Lefax), the protease inhibitor gabexate mesilate (FOY), the antimycotic ketoconazole, and the hydroxyl scavangers dimethylsulphoxide (DMSO) and allopurinol were investigated for growth inhibition of Helicobacter pylori and representative strains of other bacterial species. H. pylori were selectively inhibited by 64–128 mg/L of simethicone, 64–128 mg/L gabexate mesilate, and 16–64 mg/L ketoconazole Dimethylsulphoxide and allopurinol showed no antibacterial effect at concentrations used therapeutically. It is concluded that gabexate mesilate, ketoconazole and, particularly, simethicone are candidates for treatment of H. pylori infection.