Direct effects of 3,4‐methylenedioxymethamphetamine (MDMA) on serotonin or dopamine release and uptake in the caudate putamen, nucleus accumbens, substantia nigra pars reticulata, and the dorsal raphé nucleus slices
2000; Wiley; Volume: 36; Issue: 4 Linguagem: Inglês
10.1002/(sici)1098-2396(20000615)36
ISSN1098-2396
AutoresMahmoud M. Iravani, Daniel Asari, Jyoti C. Patel, Walter J. Wieczorek, Zygmunt L. Kruk,
Tópico(s)Forensic Toxicology and Drug Analysis
ResumoWe examined the effects of pressure ejected 3,4-methylenedioxymeth- amphetamine (MDMA) from a micropipette on direct chemically stimulated release, and on electrically stimulated serotonin (5-HT) or dopamine (DA) release in the caudate putamen (CPu), nucleus accumbens (NAc), substantia nigra pars reticulata (SNr), and the dorsal raphenucleus (DRN) brain slices of rat, using fast cyclic voltammetry (FCV). MDMA is electroactive, oxidising at 11100 mV. When the anodic input waveform was reduced from 11.4 to 11.0 volt, MDMA was not electroactive. Using this waveform, pressure ejection of MDMA did not release 5-HT or DA in brain slices prepared from any of the nuclei studied. MDMA significantly potentiated electrically stimulated 5-HT release in the SNr and DA release in CPu. In the DRN or in the NAc, MDMA was without effect on peak electrically stimulated 5-HT or DA release. The rates of neuro- transmitter uptake, expressed as t1/2, were in all cases significantly decreased after MDMA. The results indicate that MDMA, unlike (1)amphetamine, is not as a releaser of DA or 5-HT, it is a potent inhibitor of both DA and 5-HT uptake. Synapse 36: 275-285, 2000. © 2000 Wiley-Liss, Inc.
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