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Patterns of HIV-1 Drug Resistance After First-Line Antiretroviral Therapy (ART) Failure in 6 Sub-Saharan African Countries: Implications for Second-Line ART Strategies

2012; Oxford University Press; Volume: 54; Issue: 11 Linguagem: Inglês

10.1093/cid/cis254

1537-6591

Raph L Hamers, Kim Sigaloff, Annemarie M. J. Wensing, Carole L. Wallis, Cissy Kityo, Margaret Siwale, Kishor Mandaliya, Prudence Ive, M. E. Botes, Melanie Wellington, Akin Osibogun, Wendy Stevens, Tobias F. Rinke de Wit, Rob Schuurman,

HIV/AIDS Research and Interventions

Background. Human immunodeficiency virus type 1 (HIV-1) drug resistance may limit the benefits of antiretroviral therapy (ART). This cohort study examined patterns of drug-resistance mutations (DRMs) in individuals with virological failure on first-line ART at 13 clinical sites in 6 African countries and predicted their impact on second-line drug susceptibility.