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Custom-made Stent-Grafts for Aortic Aneurysm Repair Using Gianturco Z Stents and Woven Polyester: Healing in an Animal Model

2005; SAGE Publishing; Volume: 39; Issue: 1 Linguagem: Inglês

10.1177/153857440503900106

1938-9116

Fabien Koskas, Isabelle Brochériou, Philippe Cluzel, Jean-Dominique Singland, B Regnier, Michel Bonnot, Édouard Kieffer,

Infectious Aortic and Vascular Conditions

The purpose of this study was to evaluate the healing at 6 months of aortic stent-grafts custom-made by using Z stents and woven polyester in an animal model. Stent-grafts were built by a published method using autoexpandable stainless steel stents continuously compiled with polyester sutures and covered with a woven polyester membrane. Fourteen stent-grafts of 3 different designs were deployed under fluoroscopic control into the thoracic and the abdominal aorta of 7 adult sheep. At 6 months, all the implants of the sheep that survived the implantation were angiographed and harvested for macroscopy and microscopy. All stentgrafts were implanted successfully and remained patent from then to the explantation procedure. All stent-grafts implanted among the 6 of 7 (86%) animals that survived after the implantation remained patent, stayed free from local complications, and did not migrate during more than 6 months. In all these cases during this period, the implant functioned as a satisfactory aortic substitute while the aortic segment containing the graft kept a normal structure. There was no adverse effects of the presence of the implant upon the aorta or the animal. Stent-grafts home-made according to the described methods gave results at 6 months in this animal model compatible with a safe clinical application among humans.