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BIBTEX RIS

Synthesis and GABAA receptor activity of a 6,19-Oxido analogue of pregnanolone

2003; Elsevier BV; Volume: 13; Issue: 3 Linguagem: Inglês

10.1016/s0960-894x(02)01019-3

ISSN

1464-3405

Autores

Adriana S. Veleiro, Ruth E. Rosenstein, Carolina O. Jaliffa, Marı́a L Grilli, Florencia Speroni, Gerardo Burton,

Tópico(s)

Oxidative Organic Chemistry Reactions

Resumo

3α-Hydroxy-6,19-oxidopregn-4-ene-20-one (4) was prepared in seven steps from pregnanolone acetate. At 0.1 μM concentration 4 significantly increased GABA induced 36Cl− influx in hamster cerebral cortex synaptoneurosomes while at 20 mg/kg it decreased the percentage of hamsters showing seizures induced by 3-mercaptopropionic acid.

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