Portal de Periódicos da CAPES

Pattern formation in the limbs of Drosophila : bric à brac is expressed in both a gradient and a wave-like pattern and is required for specification and proper segmentation of the tarsus

1993; The Company of Biologists; Volume: 119; Issue: 3 Linguagem: Inglês

10.1242/dev.119.3.799

1477-9129

Dorothea Godt, Jean‐Louis Couderc, Sarah E. Cramton, Frank A. Laski,

Genomics and Chromatin Dynamics

ABSTRACT We have identified the gene bric à brac and show that it is required for pattern formation along the proximal-distal axis of the leg and antenna of Drosophila. In bric à brac mutant legs, the bristle pattern of the three central tarsal segments is transformed towards the pattern of the most proximal tarsal segment. In addition, bric à brac mutant legs and antennae have segmentation defects. bric à brac encodes a nuclear protein that shares a highly conserved domain with two transcription factors from Drosophila. bric à brac function is dosage dependent and is required in a graded manner for the specification of tarsal segments. The graded requirement for bric à brac correlates with its graded expression pattern, sug-gesting that the concentration of BRIC Á BRAC protein specifies segment identity in the tarsus.