The relative frequencies of HLA‐DRB1*01 alleles in the major US populations
2000; Wiley; Volume: 55; Issue: 1 Linguagem: Inglês
10.1034/j.1399-0039.2000.550108.x
ISSN1399-0039
AutoresMary Collins, Tingting Tang, Rebecca Slack, David Sintasath, R.J. Hartzman, J. Ng, Carolyn Katovich Hurley,
Tópico(s)Monoclonal and Polyclonal Antibodies Research
ResumoThe frequencies of alleles in the HLA‐DRB1*01 family were determined in each of five US populations from a database of 82,979 individuals. Individuals typed as DR1 (or DRB1*01) comprised between 7.6%–21.3% of the individuals in each population group. Fifty‐nine DR1 individuals were randomly selected from each group and subjected to high‐resolution DNA typing by polymerase chain reaction using sequence‐specific oligonucleotide probes. DRB1*0101 was the most common allele in the Caucasian, Asian/Pacific Islander, and Native American groups while the DRB1*0102 allele was found in the majority of African Americans and Hispanics. DRB1*0103 was present at a similar frequency in all populations. DRB1*0104, DRB1*0105, and DRB1*0106 alleles were not observed.
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