The cost of resistance and the maintenance of genetic polymorphism in host—pathogen systems
1994; Royal Society; Volume: 257; Issue: 1349 Linguagem: Inglês
10.1098/rspb.1994.0101
ISSN1471-2954
AutoresJanis Antonovics, Peter H. Thrall,
Tópico(s)Burkholderia infections and melioidosis
ResumoRestricted accessMoreSectionsView PDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail Cite this article Antonovics Janis and Thrall Peter H. 1994The cost of resistance and the maintenance of genetic polymorphism in host—pathogen systemsProc. R. Soc. Lond. B.257105–110http://doi.org/10.1098/rspb.1994.0101SectionRestricted accessArticleThe cost of resistance and the maintenance of genetic polymorphism in host—pathogen systems Janis Antonovics Google Scholar Find this author on PubMed Search for more papers by this author and Peter H. Thrall Google Scholar Find this author on PubMed Search for more papers by this author Janis Antonovics Google Scholar Find this author on PubMed and Peter H. Thrall Google Scholar Find this author on PubMed Published:22 August 1994https://doi.org/10.1098/rspb.1994.0101AbstractBy using models which incorporate both numerical and gene-frequency dynamics, we investigate the conditions for a stable polymorphism in host disease resistance when there is a genetically uniform pathogen. We show that polymorphism is more likely when the difference in resistance conferred by alternative alleles is large rather than small. This conforms with the frequent observation of major gene effects on resistance. Moreover, when allelic differences in resistance are large, polymorphism is possible over a wide range of costs, including situations where costs approach values close to zero. The actual resistance cost that can be sustained in such polymorphic populations is dependent on the transmission mode and the intensity of disease-independent population regulation. Expectations regarding resistance costs in any particular host—pathogen system will be dependent on knowledge of the epidemiological and genetic characteristics of that system.FootnotesThis text was harvested from a scanned image of the original document using optical character recognition (OCR) software. As such, it may contain errors. Please contact the Royal Society if you find an error you would like to see corrected. Mathematical notations produced through Infty OCR. 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