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Artigo Revisado por pares
BIBTEX RIS

Tyrosine Hydroxylase mRNA Concentration in Midbrain Dopaminergic Neurons Is Differentially Regulated by Reserpine

1990; Wiley; Volume: 55; Issue: 5 Linguagem: Inglês

10.1111/j.1471-4159.1990.tb04970.x

ISSN

1471-4159

Autores

Giulio Maria Pasinetti, David Morgan, Steve A. Johnson, Sharon L. Millar, Caleb E. Finch,

Tópico(s)

Neurotransmitter Receptor Influence on Behavior

Resumo

Abstract: Tyrosine hydroxylase (TH)‐mRNA, assayed by in situ hybridization combined with TH immunocytochemistry, showed a selective increase in the ventral tegmental area (A‐10) but not in the substantia nigra (A‐9) midbrain dopaminergic (DAergic) neurons 3 days after reserpine treatment. TH‐mRNA in locus ceruleus noradrenergic (A‐4) neurons was increased by reserpine, as confirmed by RNA blot hybridization. These findings show that TH‐mRNA is differentially regulated in midbrain DAergic neurons in response to reserpine.

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