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Biosynthesis of aminocyclitol antibiotics.

1976; Springer Nature; Volume: 29; Issue: 4 Linguagem: Inglês

10.7164/antibiotics.29.319

1881-1469

Kenneth L. Rinehart, Ronald M. Stroshane,

Synthesis and Biological Activity

The history of the aminocyclitol antibiotics dates from the discovery in 1943 of streptomycin by Waksman’s group at Rutgers (Schatz et al., 1946). This was followed by the discovery of neomycin, paromomycin, kanamycin, gentamicin, sisomicin, butirosin, ribostamycin, spectinomycin, fortimicin, validamycin, minosaminomycin, and hygromycin, to name but some of the naturally occurring members of this class of compounds.