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BIBTEX RIS

Fortimicins A and B, new aminoglycoside antibiotics. I. Producing organism, fermentation a biological properties of fortimicins.

1977; Springer Nature; Volume: 30; Issue: 7 Linguagem: Inglês

10.7164/antibiotics.30.533

ISSN

1881-1469

Autores

Takashi NARA, MITSUYOSHI YAMAMOTO, Isao Kawamoto, Kenichiro Takayama, Ryo Okachi, Seigo Takasawa, Tomoyasu Sato, Seiji Sato,

Tópico(s)

Fermentation and Sensory Analysis

Resumo

A culture of Micromonospora species MK-70 was found to produce two new antibiotics, fortimicins A and B. Antibacterial and paper chromatographic data on an eluate from IRC-50 treatment of fermentation beers indicated that fortimicins A and B are new antibiotics with broad-spectrum, basic and water-soluble properties. Fortimicin A exhibited potent, unique, broad-spectrum antibacterial activity against Gram-positive and negative bacteria both in vitro and in vivo, while fortimicin B was only weakly active.

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