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Risk factors and prevention of late-onset sepsis in premature infants

2010; Elsevier BV; Volume: 86; Issue: 1 Linguagem: Inglês

10.1016/j.earlhumdev.2010.01.012

1872-6232

L. Corbin Downey, P. Brian Smith, Daniel K. Benjamin,

Infant Development and Preterm Care

Late-onset sepsis in premature infants is a major cause of morbidity, mortality, and increased medical costs. Risk factors include low birth weight, low gestational age, previous antimicrobial exposure, poor hand hygiene, and central venous catheters. Methods studied to prevent late-onset sepsis include early feedings, immune globulin administration, prophylactic antimicrobial administration, and improved hand hygiene. In this review, we will outline the risk factors for development of late-onset sepsis and evidence supporting methods for prevention of late-onset sepsis in premature infants.