Portal de Periódicos da CAPES

New directions in ultrasound: microbubble contrast

2006; Wiley; Volume: 79; Issue: 939 Linguagem: Inglês

10.1259/bjr/17790547

1748-880X

Victoria Stewart, Paul S. Sidhu,

Ultrasound in Clinical Applications

CommentaryNew directions in ultrasound: microbubble contrastV R Stewart and P S SidhuV R StewartDepartment of Radiology, King's College Hospital, Denmark Hill, London SE5 9RS, UK and P S SidhuDepartment of Radiology, King's College Hospital, Denmark Hill, London SE5 9RS, UKPublished Online:5 Mar 2014https://doi.org/10.1259/bjr/17790547SectionsPDF/EPUBFull Text ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail About References 1 Gramiak R, Shah PM. Echocardiography of the aortic root. Invest Radiol 1968;3:356–66. Crossref Medline, Google Scholar2 Harvey CJ, Blomley MJK, Eckersley RJ, Cosgrove DO. Developments in ultrasound contrast media. Eur Radiol 2001;11:675–89. Crossref Medline ISI, Google Scholar3 Correas JM, Bridal L, Lesavre A, Mejean A, Claudon M, Helenon O. Ultrasound contrast agents: properties, principles of action, tolerance, and artifacts. Eur Radiol 2001;11:1316–28. Crossref Medline ISI, Google Scholar4 Greis C. Technology overview: SonoVue. Eur Radiol Suppl 2004;14:P11–P15. Crossref Medline ISI, Google Scholar5 Blomley MJK, Cooke JC, Unger EC, Monaghan MJ, Cosgrove DO. Microbubble contrast agents; a new era in ultrasound. BMJ 2001;322:1222–5. Crossref Medline, Google Scholar6 Leen E. Ultrasound contrast harmonic imaging of abdominal organs. Semin Ultrasound CT MRI 2001;22:11–24. Crossref Medline ISI, Google Scholar7 Simpson DH, Chin CT, Burns PN. Pulse inversion Doppler: a new method for detecting nonlinear echoes from microbubble contrast agents. IEEE Trans Biomed Engin 1999;46:372–82. Google Scholar8 Whittingham TA. Broadband transducers. Eur Radiol 1999;9:S298–S303. Crossref Medline ISI, Google Scholar9 Lim AKP, Patel N, Eckersley RJ, Taylor-Robinson SD, Cosgrove DO, Blomley MJK. Evidence for spleen-specific uptake of a microbubble contrast agent: a quantitative study in healthy volunteers. Radiology 2004;231:785–8. Crossref Medline ISI, Google Scholar10 Hauff P, Fritzsch T, Reinhardt M, Weitschies W, Luders F, Uhlendorf V, et al. Delineation of experimental liver tumors in rabbits by a new ultrasound contrast agent and stimulated acoustic emission. Invest Radiol 1997;32:95–9. Crossref ISI, Google Scholar11 Forsberg F, Goldberg BB, Liu JB, Merton DA, Rawool NM, Shi WT. Tissue-specific US contrast agent for evaluation of hepatic and splenic parenchyma. Radiology 1999;210:125–32. Crossref Medline ISI, Google Scholar12 Blomley MJK, Sidhu PS, Cosgrove DO, Albrecht T, Harvey CJ, Heckemann RA, et al. Different types of liver lesions differ in their uptake of the microbubble contrast agent SH U 508A in the late liver phase? Early experience. Radiology 2001;220:661–7. Crossref Medline ISI, Google Scholar13 Bryant TH, Blomley MJK, Albrecht T, Sidhu PS, Leen E, Basilico R, et al. Liver phase uptake of a liver specific microbubble improves characterization of liver lesions: a prospective multi-center study. Radiology 2004;232:392–9. Crossref ISI, Google Scholar14 Marshall MM, Beese RC, Muiesan P, Sarma DI, O'Grady J, Sidhu PS. Assessment of portal venous patency in the liver transplant candidate: a prospective study comparing ultrasound, microbubble-enhanced colour Doppler ultrasound with arteriography and surgery. Clin Radiol 2002;57:377–83. Crossref Medline ISI, Google Scholar15 Gebel M, Caselitz M, Bowen-Davies PE, Weber S. A multicenter, prospective, open label, randomized, controlled phase IIIb study of SH U 508A (Levovist) for Doppler signal enhancement in the portal vascular system. Ultraschall Med 1998;19:148–56. Crossref Medline ISI, Google Scholar16 Sidhu PS, Shaw AS, Ellis SM, Karani JB, Ryan SM. Microbubble ultrasound contrast in the assessment of hepatic artery patency following liver transplantation: role in reducing frequency of hepatic artery arteriography. Eur Radiol 2004;14:21–30. Crossref Medline ISI, Google Scholar17 Tano S, Ueno N, Tomiyama T, Kimura K. Possibility of differentiating small hyperechoic liver tumours using contrast-enhanced colour Doppler ultrasonography: a preliminary study. Clin Radiol 1997;52:41–5. Crossref Medline ISI, Google Scholar18 Albrecht T, Blomley MJK, Bolondi L, Claudon M, Correas JM, Cosgrove DO, et al. Guidelines for the use of contrast agents in ultrasound. January 2004. Ultraschall Med 2004;25:249–56. Crossref Medline ISI, Google Scholar19 Albrecht T, Hohmann J, Oldenburg A, Skork J, Wolf KJ. Detection and characterisation of liver metastases. Eur Radiol Suppl 2004;14:P25–P33. Medline ISI, Google Scholar20 Bleuzen A, Tranquart F. Incidental liver lesions: diagnostic value of cadence contrast pulse sequencing (CPS) and SonoVue. Eur Radiol Suppl 2004;14:P53–P62. Crossref Medline ISI, Google Scholar21 Kim KW, Choi BI, Park SH, Kim AY, Koh YH, Lee HJ, et al. Pyogenic hepatic abscesses: distinctive features from hypovascular hepatic malignancies on contrast-enhanced ultrasound with SH U 508A; early experience. Ultrasound Med Biol 2004;30:725–33. Crossref Medline ISI, Google Scholar22 Berry JD, Boxer ME, Rashid HI, Sidhu PS. Microbubble contrast enhanced ultrasound characteristics of multiple biliary hamartomas (von Meyenberg complexes). Ultrasound 2004;12:95–7. Crossref, Google Scholar23 Leen E, Moug S, Horgan P. Potential impact and utilization of ultrasound contrast media. Eur Radiol Suppl 2004;14:P16–P24. Crossref Medline ISI, Google Scholar24 Siosteen AK, Elvin A. Intra-operative uses of contrast-enhanced ultrasound. Eur Radiol Suppl 2004;14:P87–P95. Medline ISI, Google Scholar25 Solbiati L, Tonolini M, Cova L. Monitoring RF ablation. Eur Radiol Suppl 2004;14:P34–P42. Crossref Medline ISI, Google Scholar26 Wen YL, Kudo M, Zheng RQ, Minami Y, Chung H, Suetomi Y, et al. Radiofrequency ablation of hepatocellular carcinoma: therapeutic response using contrast-enhanced coded phase-inversion harmonic sonography. AJR Am J Roentgenol 2003;181:57–63. Crossref Medline ISI, Google Scholar27 Grant EG. Sonographic contrast agents in vascular imaging. Semin Ultrasound CT MRI 2001;22:25–41. Crossref Medline ISI, Google Scholar28 Satchithananda K, Sellars MEK, Ryan SM, Sidhu PS. Microbubble ultrasound contrast agents in the visualization of peripheral vasculature in 'Doppler rescue': a review. Ultrasound 2004;12:176–84. Crossref, Google Scholar29 Darge K, Troeger J, Duetting T, Zieger B, Rohrschneider W, Moehring K, et al. Reflux in young patients: comparison of voiding US of the bladder and retrovesical space with echo enhancement versus voiding cystourethrography for diagnosis. Radiology 1999;210:201–7. Crossref Medline ISI, Google Scholar30 Darge K, Troeger J. Vesicoureteral reflux grading in contrast-enhanced voiding urosonography. Eur J Radiol 2002;43:122–8. Crossref Medline ISI, Google Scholar31 Catalano O, Lobianco R, Raso MM, Siani A. Blunt hepatic trauma: evaluation with contrast-enhanced sonography. J Ultrasound Med 2005;24:299–310. Crossref Medline ISI, Google Scholar32 Catalano O, Lobianco R, Sandomenico F, Siani A. Splenic trauma: evaluation with contrast-specific sonography and a second generation contrast medium. J Ultrasound Med 2003;22:467–77. Crossref Medline ISI, Google Scholar33 Oldenburg A, Hohmann J, Skork J, Albrecht T. Imaging of pediatric splenic injury with contrast-enhanced ultrasonography. Pediatr Radiol 2004;34:351–4. Crossref Medline ISI, Google Scholar34 Poletti PA, Platon A, Becker CD, Mentha G, Vermeulen B, Buhler LH, et al. Blunt abdominal trauma: does the use of a second-generation sonographic contrast agent help to detect solid organ injuries? AJR Am J Roentgenol 2004;183:1293–301. Crossref Medline ISI, Google Scholar35 Farahmand N, Sirlin CB, Brown MA, Shragg GP, Fortlage D, Hoyt DB, et al. Hypotensive patients with blunt abdominal trauma: performance of screening US. Radiology 2005;235:436–43. Crossref Medline ISI, Google Scholar36 Cosgrove DO, Kedar RP, Bamber JC, Al-Murrani B, Davey JBN, Fisher C, et al. Breast disease: color Doppler US in differential diagnosis. Radiology 1993;189:99–104. Crossref Medline ISI, Google Scholar37 Cosgrove DO, Bamber JC, Davey JB, McKinna JA, Sinnett HD. Color Doppler signals from breast tumors. Work in progress. Radiology 1990;176:175–80. Crossref Medline ISI, Google Scholar38 Kedar RP, Cosgrove DO, McCready VR, Bamber JC, Carter ER. Microbubble contrast agent for color Doppler US: effect on breast masses - work in progress. Radiology 1996;198:679–86. Crossref Medline ISI, Google Scholar39 Kook SH, Kwag HJ. Value of contrast-enhanced power Doppler sonography using a microbubble echo-enhancing agent in evaluation of small breast lesions. J Clin Ultrasound 2003;31:227–38. Crossref Medline ISI, Google Scholar40 Lamuraglia M, Lassau N, Garbay JR, Mathieu MC, Rouzier R, Jaziri S, et al. Doppler US with perfusion software and contrast medium injection in the early evaluation of radiofrequency in breast cancer recurrences: a prospective phase II study. Eur J Radiol 2005;6 Medline ISI, Google Scholar41 Goldberg BB, Merton DA, Liu JB, Thakur M, Murphy GF, Needleman L, et al. Sentinel lymph nodes in a swine model with melanoma: contrast-enhanced lymphatic US. Radiology 2004;230:727–34. Crossref Medline ISI, Google Scholar42 Bostick PJ, Guiliano AE. Vital dyes in sentinel node localization. Semin Nucl Med 2000;30:18–24. Crossref Medline ISI, Google Scholar43 Hauff P, Reinhardt M, Briel A, Debus N, Schirner M. Molecular targeting of lymph nodes with l-selectin ligand-specific US contrast agent: a feasibility study in mice and dogs. Radiology 2004;231:667–73. Crossref Medline ISI, Google Scholar44 Goldberg BB, Merton DA, Liu JB, Murphy G, Forsberg F. Contrast-enhanced sonographic imaging of lymphatic channels and sentinel lymph nodes. J Ultrasound Med 2005;24:953–65. Crossref Medline ISI, Google Scholar45 Magarelli N, Guglielmi G, Di Matteo L, Tartaro A, Mattei PA, Bonomo L. Diagnostic utility of an echo-contrast agent in patients with synovitis using power Doppler ultrasound: a preliminary study with comparison to contrast-enhanced MRI. Eur Radiol 2001;11:1039–46. Crossref Medline ISI, Google Scholar46 Szkudlarek M, Court-Payen M, Strandberg C, Klarlund M, Klausen T, Oÿstergaard M. Contrast-enhanced power Doppler ultrasonography of the metacarpophalangeal joints in rheumatoid arthritis. Eur Radiol 2003;13:163–8. Medline ISI, Google Scholar47 North American Symptomatic Carotid Endarterectomy Trial Collaborators. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med 1991;325:445–53. Crossref Medline ISI, Google Scholar48 European Carotid Surgery Trialists' Collaborative Group. Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST). Lancet 1998;351:1379–87. Crossref Medline ISI, Google Scholar49 Ferrer JME, Samso JJ, Serrando JR, Valenzuela VF, Montoya SB, Docampo MM. Use of ultrasound contrast in the diagnosis of carotid artery occlusion. J Vasc Surg 2000;31:736–41. Crossref Medline ISI, Google Scholar50 Kono Y, Pinnell SP, Sirlin CB, Sparks SR, Georgy B, Wong W, et al. Carotid arteries: contrast-enhanced US angiography--preliminary clinical experience. Radiology 2004;230:561–8. Crossref Medline ISI, Google Scholar51 Miller MW. Gene transfection and drug delivery. Ultrasound Med Biol 2000;26:S59–S62. Crossref Medline ISI, Google Scholar52 Taniyama Y, Tachibana K, Hiraoka K, Aoki M, Yamamoto S, Matsumoto K, et al. Development of safe and efficient novel nonviral gene transfer using ultrasound: enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle. Gene Ther 2002;9:372–80. Crossref Medline ISI, Google Scholar53 Lu QL, Liang HD, Partridge T, Blomley MJ. Microbubble ultrasound improves the efficiency of gene transduction in skeletal muscle in vivo with reduced tissue damage. Gene Ther 2003;10:396–405. Crossref Medline ISI, Google Scholar54 Tachibana K, Uchida T, Ogawa K, Yamashita N, Tamura K. Induction of cell-membrane porosity by ultrasound. Lancet 1999;353:1409 Crossref Medline ISI, Google Scholar55 Li T, Tachibana K, Kuroki M, Kuroki M. Gene transfer with echo-enhanced contrast agents: comparison between albunex, optison, and levovist in mice--initial results. Radiology 2003;229:423–8. Crossref Medline ISI, Google Scholar56 Blomley M. Which US microbubble contrast agent is best for gene therapy? Radiology 2003;229:297–8. Crossref Medline ISI, Google Scholar57 Jakobsen JA, Oyen R, Thomsen HS, Morcos SK. Safety of ultrasound contrast agents. Eur Radiol 2005;15:941–5. Crossref Medline ISI, Google Scholar58 Crucinio N, Nacchiero MC, Panella C, Ierardi E. A case of adverse reaction potentially related to a microbubble contrast agent for ultrasonography. Eur J Radiol (Extra) 2004;52:25–6. Crossref, Google Scholar59 van der Wouw P, Brauns A, Bailey S, Powers J, Wilde A. Premature ventricular contractions during triggered imaging with ultrasound contrast. J Am Soc Echocardiogr 2000;13:288–94. Crossref Medline ISI, Google Scholar60 Sidhu PS. Microbubbles are here to be burst! Radiology Now 2003;20:2–3. Google Scholar Previous article Next article FiguresReferencesRelatedDetailsCited byEnhanced sonodynamic therapy by carbon dots-shelled microbubbles with focused ultrasoundUltrasonics Sonochemistry, Vol. 94Cur-loaded magnetic [email protected] composites as dual pH- and ultrasound responsive nano-carriers for controlled and targeted cancer chemotherapyMaterials Chemistry and Physics, Vol. 271Tumor VasculatureImaging characteristics of intravascular spherical contrast agents for grating-based x-ray dark-field imaging – effects of concentrations, spherical sizes and applied voltage10 June 2020 | Scientific Reports, Vol. 10, No. 1In situ conversion of rose bengal microbubbles into nanoparticles for ultrasound imaging guided sonodynamic therapy with enhanced antitumor efficacy1 January 2020 | Biomaterials Science, Vol. 8, No. 9Magnetic microbubble mediated chemo-sonodynamic therapy using a combined magnetic-acoustic deviceJournal of Controlled Release, Vol. 317Acidic pH-Activated Gas-Generating Nanoparticles with Pullulan Decorating for Hepatoma-Targeted Ultrasound Imaging4 June 2019 | ACS Applied Materials & Interfaces, Vol. 11, No. 25Concurrent photoacoustic and ultrasound microscopy with a coaxial dual-element ultrasonic transducer5 September 2018 | Visual Computing for Industry, Biomedicine, and Art, Vol. 1, No. 1Magnetically responsive microbubbles as delivery vehicles for targeted sonodynamic and antimetabolite therapy of pancreatic cancerJournal of Controlled Release, Vol. 262Chemical gas-generating nanoparticles for tumor-targeted ultrasound imaging and ultrasound-triggered drug deliveryBiomaterials, Vol. 108Self and Mutual Radiation Impedances for Modeling of Multi-Frequency CMUT ArraysIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Vol. 63, No. 9Mutual radiation impedance for modeling of multi-frequency CMUT arraysMicrobubble embedded with upconversion nanoparticles as a bimodal contrast agent for fluorescence and ultrasound imaging5 August 2015 | Nanotechnology, Vol. 26, No. 34Oxygen carrying microbubbles for enhanced sonodynamic therapy of hypoxic tumoursJournal of Controlled Release, Vol. 203pH-Controlled Gas-Generating Mineralized Nanoparticles: A Theranostic Agent for Ultrasound Imaging and Therapy of Cancers8 January 2015 | ACS Nano, Vol. 9, No. 1van der Waals force-induced loading of proangiogenic nanoparticles on microbubbles for enhanced neovascularization1 January 2015 | Nanoscale, Vol. 7, No. 40Contrast Evaluation of Liver MassesUltrasound Clinics, Vol. 9, No. 4Echogenic nanoparticles for ultrasound technologies: Evolution from diagnostic imaging modality to multimodal theranostic agentNano Today, Vol. 9, No. 4VEGFR2-Targeted Molecular Imaging in the Mouse Embryo: An Alternative to the Tumor ModelUltrasound in Medicine & Biology, Vol. 40, No. 2Microbubble Applications in BiomedicineLiver-Specific and Echogenic Hyaluronic Acid Nanoparticles Facilitating Liver Cancer Discrimination19 June 2013 | Advanced Functional Materials, Vol. 23, No. 44Non-invasive quantification of tumor vascular architecture during docetaxel-chemotherapy22 March 2012 | Breast Cancer Research and Treatment, Vol. 134, No. 3Microbubble–sonosensitiser conjugates as therapeutics in sonodynamic therapyChemical Communications, Vol. 48, No. 67Polymeric Imaging AgentsMedical ultrasound: imaging of soft tissue strain and elasticity16 June 2011 | Journal of The Royal Society Interface, Vol. 8, No. 64Pancreatic splenosis demonstrated by contrast-enhanced sonography4 May 2011 | Journal of Clinical Ultrasound, Vol. 39, No. 6Color Doppler sonography: characterizing breast lesionsImaging in Medicine, Vol. 2, No. 2Microbubbles as x-ray scattering contrast agents using analyzer-based imaging24 February 2010 | Physics in Medicine and Biology, Vol. 55, No. 6Contrast-enhanced ultrasonography (CEUS) in canine liver examinationPolish Journal of Veterinary Sciences, Vol. 13, No. 4Preparation of Perfluorocarbon/Fluoroalkyl Polymer Nanodroplets for Cancer-targeted Ultrasound Contrast AgentsChemistry Letters, Vol. 38, No. 6Molecular Imaging in CancerCommentary: Will magnetic resonance imaging (MRI)-based contrast agents for molecular receptor imaging make their way into the clinic?26 November 2007 | Journal of Cellular and Molecular Medicine, Vol. 12, No. 1Assessment of hepatic VX2 tumors with combined percutaneous transhepatic lymphosonography and contrast-enhanced ultrasonographic imagingWorld Journal of Gastroenterology, Vol. 14, No. 24Contrast ultrasound: General principles and veterinary clinical applicationsThe Veterinary Journal, Vol. 174, No. 3Molecular–functional imaging of cancer: to image and imagineTrends in Molecular Medicine, Vol. 13, No. 7Monitoring Response to Anticancer Therapy by Targeting Microbubbles to Tumor Vasculature2 January 2007 | Clinical Cancer Research, Vol. 13, No. 1Advanced applications of breast ultrasound Volume 79, Issue 939March 2006Pages: 183-270 © The British Institute of Radiology History RevisedSeptember 23,2005ReceivedJuly 19,2005AcceptedOctober 05,2005Published onlineMarch 05,2014 Metrics Download PDF