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Associations between CYP2B6 Polymorphisms and Pharmacokinetics after a Single Dose of Nevirapine or Efavirenz in African Americans

2009; Oxford University Press; Volume: 199; Issue: 6 Linguagem: Inglês

10.1086/597125

1537-6613

David W. Haas, Tebeb Gebretsadik, Gail Mayo, Usha N. Menon, Edward P. Acosta, Ayumi Shintani, Michael D. Floyd, C. Michael Stein, G. Wilkinson,

HIV Research and Treatment

Polymorphisms in CYP2B6 affect the steady-state plasma concentrations of nevirapine and efavirenz. In many resource-limited countries, a single dose of nevirapine has been widely prescribed to pregnant women at delivery, to reduce mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1). We characterized associations between genetic polymorphisms and the pharmacokinetics of single doses of nevirapine and efavirenz.