Portal de Periódicos da CAPES

Immunological Characteristics of Islet Cell Xenotransplantation in Humans and Rodents

1994; Wiley; Volume: 141; Issue: 1 Linguagem: Inglês

10.1111/j.1600-065x.1994.tb00878.x

1600-065X

Masahiro Satake, Olle Korsgren, Anna Ridderstad, Alex Karlsson‐Parra, AnnaCarin Wallgren, Erna Möller,

Anesthesia and Neurotoxicity Research

Immunological ReviewsVolume 141, Issue 1 p. 191-211 Immunological Characteristics of Islet Cell Xenotransplantation in Humans and Rodents Masahiro Satake, Masahiro Satake Division of Clinical Immunology, Department of Immunology, Microbiology, Pathology and Infectious Diseases, Karolinska Institute, Huddinge hospital M. Satake and O. Korsgren contributed equally to this report.Search for more papers by this authorOlle Korsgren, Olle Korsgren Department of Clinical Immunology and Transfusion Medicine, University Hospital, Uppsala M. Satake and O. Korsgren contributed equally to this report.Search for more papers by this authorAnna Ridderstad, Anna Ridderstad Department of Immunology, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.Search for more papers by this authorAlex Karlsson-Parra, Alex Karlsson-Parra Department of Clinical Immunology and Transfusion Medicine, University Hospital, UppsalaSearch for more papers by this authorAnna-Carin Wallgren, Anna-Carin Wallgren Department of Clinical Immunology and Transfusion Medicine, University Hospital, UppsalaSearch for more papers by this authorErna Möller, Erna Möller Division of Clinical Immunology, Department of Immunology, Microbiology, Pathology and Infectious Diseases, Karolinska Institute, Huddinge hospital Department of Immunology, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.Search for more papers by this author Masahiro Satake, Masahiro Satake Division of Clinical Immunology, Department of Immunology, Microbiology, Pathology and Infectious Diseases, Karolinska Institute, Huddinge hospital M. Satake and O. Korsgren contributed equally to this report.Search for more papers by this authorOlle Korsgren, Olle Korsgren Department of Clinical Immunology and Transfusion Medicine, University Hospital, Uppsala M. Satake and O. Korsgren contributed equally to this report.Search for more papers by this authorAnna Ridderstad, Anna Ridderstad Department of Immunology, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.Search for more papers by this authorAlex Karlsson-Parra, Alex Karlsson-Parra Department of Clinical Immunology and Transfusion Medicine, University Hospital, UppsalaSearch for more papers by this authorAnna-Carin Wallgren, Anna-Carin Wallgren Department of Clinical Immunology and Transfusion Medicine, University Hospital, UppsalaSearch for more papers by this authorErna Möller, Erna Möller Division of Clinical Immunology, Department of Immunology, Microbiology, Pathology and Infectious Diseases, Karolinska Institute, Huddinge hospital Department of Immunology, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.Search for more papers by this author First published: October 1994 https://doi.org/10.1111/j.1600-065X.1994.tb00878.xCitations: 26 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES Auchincloss, H. Jr. (1990) Xenografting: A review. Transplantation Reviews. 4, 14. Auchincloss, H. Jr. (1988) Xenogeneic transplantation. Transplantation. 46, 1. Cary, N., Moody, J., Yannoutsos, N., Wallwork, J. & White, D. J. G. (1993) Tissue expression of human decay accelerating factor, a regulator of complement activation expressed in mice: a potential approach to inhibition of hyperacute xenograft rejection. Transplant. Proc. 25, 400. Cooper, D. K. C., Ye, Y., Rolf, L. L. Jr. & Zuhdi, N. (1991) The pigs as potential organ donor for man. In Xenotransplantation. The transplantation of organs and tissues between species. D. K. C. Cooper, E. Kemp, K. Reemtsma & D. J. G. White, eds. Springer-Verlag, Berlin . 481. Dabkowski, P. L., Vaughan, H. A., McKenzie, I. F. & Sandrin, M. S. (1993) Characterization of a cDNA clone encoding the pig alpha 1,3 galactosyltransferase: implications for xenotransplantation. Transplant. Proc. 25, 2921. Dickneite, G., Schorlemmer, H. V. & Sedlaceck, H. H. (1987) Decrease of mononuclear phagocyte cell functions and prolongation of graft survival in experimental transplantation by 15-deoxyspergualin. Int. J. Immunopharmacol. 9, 559. Galili, U., Macher, B. A., Buehler, J. & Shohet, S. B. (1985) Human natural anti-α-galactosyl IgG. IL The specific recognition of α(1→3)-linked galactose residues. J. Exp. Med. 162, 573. Galili, U., Shohet, S. B., Kobrin, E., Stults, C. L. M. & Macher, B. A. (1988) Man, apes, and old world monkeys differ from other mammals in the expression of α-galactosyl epitopes on nucleated cells. J. Biol Chem. 263, 17755. Gannedahl, G., Karlsson-Parra, A., Wallgren, A., Roos-Engstrand, E., Nilsson, B., Tötterman, T & Tufveson, G. (1994) Role of antibody synthesis and complement activation in concordant xenograft retransplantation. Transplantation. (in press). Gill, R. (1992) The role of T lymphocyte subsets in islet xenograft rejection. Presented at the XIV International Congress of the Transplantation Society. Good, A. H., Cooper, D. K. C., Malcolm, A. J., Ippolito, R. M., Koren, E., Neethling, F. A., Ye, Y., Zuhdi, N. & Lamontagne, L. R. (1992) Identification of carbohydrate structures that bind human antiporcine antibodies; Implications for discordant xenografting in humans. Transplant. Proc. 24, 559. Groth, C. G., Andersson, A., Korsgren, O., Tibell, A., ToUemar, J., Kumagai-Braesch, M., Möller, E., Bolinder, J., Östman, J., & Bjoersdorff, A. (1993) Transplantation of porcine fetal islet-like cell clusters into eight diabetic patients. Transplant. Proc. 25, 970. Groth, C. G., Korsgren, O., Tibell, A., Tötterman, J., Möller, E., Bolinder, J., Ostman, J., Reinholt, F., Hellerström, C. & Andersson, A. Transplantation of porcine fetal pancreas to diabetic patients: Biochemical and histological evidence of xenograft survival. (Submitted for publication). Holgersson, J., Cairns, T. D. H., Karlsson, E. C., Bäcker, A. E., Breimer, M. E., Taube, D. H., Welsh, K. I. & Samuelsson, B. E. (1992) Carbohydrate specificity of human immunoglobulin-M antibodies with pig lymphocytotoxic activity. Transplant. Proc. 24, 605. Hourcade, D., Holers, V. M. & Atkinson, J. P. (1989) The regulators of complement activation (RCA) gene cluster. Adv. Immunol. 45, 381. Irwin, M. J., Heath, W. R. & Sherman, L. A. (1989) Species-restricted interactions between CD8 and the α3 domain of class I influence the magnitude of the xenogeneic response. J. Exp. Med. 170, 1091. Kalinke, U., Arnold, B. & Hämmerling, G. J. (1990) Strong xenogeneic HLA response in transgenic mice after introducing an α3 domain into HLA B27. Nature. 348 642. Kaufman, D. B., Platt, J. L., Rabe, F. L., Dunn, D. L., Bach, F. H. & Sutherland, D. E. R. (1990) Differential roles of Mac-1+cells, and CD4+ and CD8+ T lymphocytes in primary nonfunction and classic rejection of islet allografts. J. Exp. Med. 172, 291. Kirk, A. D., Li, R. A., Kinch, M. S., Abernethy, K. A., Doyle, C. & Bollinger, R. R. (1993) The human antiporcine cellular repertoire. Transplantation. 55, 924. Koren, E., Neethling, F. A. Richards, S., Koscec, M., Ye, Y., Zuhdi, N. & Cooper, D. K. C. (1993) Binding and specificity of major immunoglobulin classes of preformed human anti-pig heart antibodies. Transplant Int. 6, 351. Korsgren, O., Andersson, A. & Sandler, S. (1993) Pretreatment of fetal porcine pancreas in culture with nicotinamide accelerates reversal of diabetes after transplantation to nude mice. Surgery. 113, 205. Korsgren, O. & Jansson, L. (1994a) Discordant cellular xenografts revascularized in intermediate athymic hosts fail to induce a hyperacute rejection when transplanted to immunocompetent rats. Transplantation. (in press). Korsgren, O. & Jansson, L. (1994a) Characterization of mixed syngeneic-allogeneic and syngeneic-xenogeneic islet graft rejection in mice: evidence of functional impairment of the remaining syngeneic islets in xenograft rejection. J. Clin. Invest. 93, 1113. Korsgren, O., Jansson, L., Eizirik, D. & Andersson, A. (1991) Functional and morphological differentiation of fetal porcine islet-like cell clusters after transplantation into nude mice. Diabetologia. 34, 379. Kumagai-Braesch, M., Satake, M., Korsgren, O., Andersson, A. & Möller, E. (1993) Characterization of cellular anti-poreine xenoreactivity, Clin. Transplantation. 7, 273. Leither, E. H. (1987) Murine macrophages and pancreatic β-cell. Chemotactic properties of insulin and β-cytostatic action of interleukin-1. J. Exp. Med. 166, 1174. Leventhal, J. R., Matas, A. J., Sun, L. H., Reif, S., Bolman III, R. M., Dalmasso, A. P. & Platt, J. L. (1993) The immunopathology of cardiac xenograft rejection in the guinea pig-to-rat model. Transplantation. 56, 1. Lindahl, K. F. & Bach, F. H. (1975) Human lymphocytes recognize mouse alloantigens. Nature. 254, 607. Markmann, J. F., Jacobson, J. D., Kimura, H., Choti, M. A., Hickey, W. F., Fox, I. J., Silvers, W. K., Barker, C. F. & Naji, A. (1989) Modulation of the major hiostocompatibility complex antigen and the immunogenicity of islet allografts. Transplantation. 48, 478. Möller, E. (1965) Contact-induced cytotoxicity by tymphoid cells containing foreign isoantigens. Science. 147, 873. Möller, E. & Möller, G. (1962) Quantitative studies of the sensitivity of normal and neoplastic cells to the cytotoxic action of isoantibodies. J. Exp. Med. 115, 527. Pierson, R. N., Winn, H. J., Russell, P.S. & Auchincloss, H. Jr. Xenogeneic skin graft rejection Is especially dependent on CD4+ T cells. J. Exp. Med. 170, 991 Ross, J. R., Kirk, A. D., Ibrahim, S. E., Howell, D. N., Baldwin III, W. M. & Sanfilippo, F. P. (1993) Characterization of human anti-porcine “natural antibodies” recovered from ex vivo perfused hearts - predominance of IgM and IgG2 Transplantation. 55, 1144. Rydberg, L., Cairns, T. D. H., Groth, C. G., Gustavsson, M. L., Karlsson, E. C., Möller, E., Satake, M., Tibell, A. & Samuelsson, B. E. (1994) Xenotransplantation of pig islet cells to man: Specificities of human IgM and IgG anticarbohydrate antibodies. Xenotransplantation. (in press). Sakakibara, N., Click, R., Sakakibara, K., Aziz, S., Jamieson, S. & Wick, M. (1990) Unconventional lymphocytes involved in rejection of xenogeneic heart grafts. Lab. Invest. 62, 481. Sandler, S., Eizirik, D. L., Svensson, C., Strandell, E., Welsh, N. & Welsh, N. (1991) Biochemical and molecular actions of interleukin-1 on pancreatic β-cells. Autoimmunity. 10, 241. Satake, M., Kumagai-Braesch, M., Kawagishi, N., Tibell, A., Groth, C. G. & Möller, E. (1994a) Kinetics and character of xenoantibody formation in diabetic patients transplanted with fetal porcine islet cell clusters. Xenotransplantation. (in press). Satake, M., Kawagishi, N., Rydberg, L., Samuelsson, B. E., Tibell, A., Groth, C. G. & Möller, E. (1994b) Limited specificity of xenoantibodies in diabetic patients transplanted with fetal porcine islet cell clusters. Main antibody reactivity against α-linked galactose-containing epitopes. Xenotransplantation. (in press). Satake, M., Kumagai-Braesch, M., Korsgren, O., Andersson, A. & Möller, E. (1993) Characterization of humoral human anti-porcine xenoreactivity Clin. Transplantation. 7, 281. Simeonovic, C. J., Ceredig, R. & Wilson, J. D. (1990) Effect of GK 1.5 monoclonal antibody dosage on survival of pig proislet xenografts in CD4+ T cell-depleted mice. Transplantation. 49, 849. Spiro, R. G. & Bhoyroo, V. D. (1984) Occurrence of α-D-galactosyl residues in the thyroglobulins from several species. J Biol Chem. 259, 9858. Szymanowski, Z., Stetkiewicz, S. & Wachler, B. (1926) Les groupes sérologiques dans le sang du pore et leur relation avec les groupes du sang humain. Compt. Rend. Soc. Biol. 94, 204. Citing Literature Volume141, Issue1October 1994Pages 191-211 ReferencesRelatedInformation