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Exon 8 splice site mutations in the gene encoding the E3-ligase CBL are associated with core binding factor acute myeloid leukemias

2008; Ferrata Storti Foundation; Volume: 93; Issue: 10 Linguagem: Inglês

10.3324/haematol.13187

1592-8721

Safdar Abbas, Gabriëlle Rotmans, Bob Löwenberg, Peter J.M. Valk,

Ubiquitin and proteasome pathways

Acute myeloid leukemia (AML) is a heterogeneous disease with diverse genetic abnormalities and variable response to treatment. In the last decade the diverse genetic abnormalities have refined risk-stratification of AML.[1][1] Recently, mutations in the Casitas B-cell lymphoma gene encoding the E3-