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Analgesic and anti-inflammatory activity of aqueous root extract of Cassia sieberiana D. C. (Caesalpiniaceae)

2009; Academic Journals; Volume: 3; Issue: 12 Linguagem: Inglês

1996-0816

Guata Yoro Sy, Alioune Fall, William Diatta, M. Gueye, Kady Diatta Badji, E Bassène, Babacar Faye,

Phytochemistry and Bioactive Compounds

The analgesic and anti-inflammatory activity of Cassia sieberiana roots were investigated. Analgesic activity had been investigated using acetic acid induced contortions in mice. The aqueous root extract of C. sieberiana at 300 mg/kg per os showed similar analgesic activity than 100 mg/kg of acetylsalicylic acid (20 ± 1.14 vs 26 ± 1.79 contortions) (ns, p < 0.05). In rat paw oedema model, C. sieberiana aqueous root extract significantly decreased carrageenan-induced oedema. These results showed that aqueous root extract of C. sieberiana possessed both analgesic and anti-inflammatory activities, which have justified their use in Senegal traditional medicine to treat pain and inflammation.