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Derivation of Dendritic Cells from Myeloid and Lymphoid Precursors

2001; Taylor & Francis; Volume: 20; Issue: 1 Linguagem: Inglês

10.3109/08830180109056726

1563-5244

Li Wu, Stéphane Vandenabeele, Katia Georgopoulos,

Immune Response and Inflammation

The antigen presenting dendritic cells (DC) found in mouse and human lymphoid tissues are heterogeneous. Several subsets of mature DC have been described and these may correspond to distinct lineages. In this review, we present evidence obtained from a series of studies on the lineage origin of DC. This evidence points to the existence of at least three pathways for DC development, namely one from mycloid progenitors, a second from lymphoid progenitors and the third for Langerhans cells from precursors whose relationship to myeloid or lymphoid cell types is not yet clearly defined.