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Drug metabolism in hepatosplenic schistosomiasis in the Sudan: a study with antipyrine.

1978; BMJ; Volume: 19; Issue: 9 Linguagem: Inglês

10.1136/gut.19.9.808

1468-3288

M Homeida, S Y Salih, R A Branch,

Parasites and Host Interactions

The disposition of antipyrine following oral administration of 1200 mg has been investigated in 10 patients with histologically confirmed hepatosplenic schistosomiasis and 11 normal subjects living in Sudan. Drug metabolising activity as assessed by antipyrine clearance was similar in patients when compared with normal controls. We conclude that antipyrine disposition is normal in patients with clinically compensated hepatosplenic schistosomiasis.