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Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host

2006; American Association for the Advancement of Science; Volume: 313; Issue: 5794 Linguagem: Inglês

10.1126/science.1131864

1095-9203

Melanie Meyer‐Luehmann, Janaky Coomaraswamy, Tristan Bolmont, Stephan A. Kaeser, Claudia Schaefer, Ellen Kilger, Anton Neuenschwander, Dorothée Abramowski, Pascal Frey, Anneliese L. Jaton, J. M. Vigouret, Paolo Paganetti, Dominic M. Walsh, Paul M. Mathews, Jorge Ghiso, Matthias Staufenbiel, Lary C. Walker, Mathias Jucker,

Neurological diseases and metabolism

Protein aggregation is an established pathogenic mechanism in Alzheimer's disease, but little is known about the initiation of this process in vivo. Intracerebral injection of dilute, amyloid-beta (Abeta)-containing brain extracts from humans with Alzheimer's disease or beta-amyloid precursor protein (APP) transgenic mice induced cerebral beta-amyloidosis and associated pathology in APP transgenic mice in a time- and concentration-dependent manner. The seeding activity of brain extracts was reduced or abolished by Abeta immunodepletion, protein denaturation, or by Abeta immunization of the host. The phenotype of the exogenously induced amyloidosis depended on both the host and the source of the agent, suggesting the existence of polymorphic Abeta strains with varying biological activities reminiscent of prion strains.