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Prenatal diagnosis of lissencephaly

1991; Wiley; Volume: 11; Issue: 3 Linguagem: Inglês

10.1002/pd.1970110302

1097-0223

Daniel H. Saltzman, Celeste M. Krauss, Janet M. Goldman, Beryl R. Benacerraf,

Infectious Encephalopathies and Encephalitis

We report two cases of prenatal detection of lissencephaly by high-resolution ultrasound. The first case studied was referred for high-risk obstetrical management and serial antenatal ultrasounds because of a family history of lissencephaly in an unresolved chromosomal abnormality. Diagnosis of a smooth gyral pattern consistent with lissencephaly was made at 32 weeks' gestation. The second case was referred for prenatal ultrasound because of a size versus dates discrepancy. The ultrasound examination showed a smooth gyral pattern at 31.5 weeks. In light of this ultrasound finding, a fetal blood sample was obtained and a chromosomal abnormality reported, confirming the diagnosis. To our knowledge, these cases represent the first report of the sonographic prenatal diagnosis of cerebral agyria or lissencephaly.