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Sexually Transmitted Infections and Prostatic Inflammation/Cell Damage as Measured by Serum Prostate Specific Antigen Concentration

2006; Lippincott Williams & Wilkins; Volume: 175; Issue: 5 Linguagem: Inglês

10.1016/s0022-5347(05)00892-x

1527-3792

Siobhan Sutcliffe, Jonathan M. Zenilman, Khalil G. Ghanem, Rosemary A. Jadack, Lori J. Sokoll, Debra J. Elliott, William G. Nelson, Angelo M. De Marzo, Stephen R. Cole, William B. Isaacs, Elizabeth A. Platz,

Urologic and reproductive health conditions

No AccessJournal of UrologyInvestigative urology1 May 2006Sexually Transmitted Infections and Prostatic Inflammation/Cell Damage as Measured by Serum Prostate Specific Antigen Concentration Siobhan Sutcliffe, Jonathan M. Zenilman, Khalil G. Ghanem, Rosemary A. Jadack, Lori J. Sokoll, Debra J. Elliott, William G. Nelson, Angelo M. De Marzo, Stephen R. Cole, William B. Isaacs, and Elizabeth A. Platz Siobhan SutcliffeSiobhan Sutcliffe Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins Medical Institutions, Baltimore, Maryland , Jonathan M. ZenilmanJonathan M. Zenilman Department of Medicine (Division of Infectious Diseases), Johns Hopkins Medical Institutions, Baltimore, Maryland , Khalil G. GhanemKhalil G. Ghanem Department of Medicine (Division of Infectious Diseases), Johns Hopkins Medical Institutions, Baltimore, Maryland , Rosemary A. JadackRosemary A. Jadack College of Nursing and Health Sciences, University of Wisconsin, Eau Claire, Wisconsin , Lori J. SokollLori J. Sokoll Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland , Debra J. ElliottDebra J. Elliott Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland , William G. NelsonWilliam G. Nelson Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland Department of Pharmacology, Johns Hopkins Medical Institutions, Baltimore, Maryland James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland , Angelo M. De MarzoAngelo M. De Marzo Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland , Stephen R. ColeStephen R. Cole Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins Medical Institutions, Baltimore, Maryland , William B. IsaacsWilliam B. Isaacs James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland , and Elizabeth A. PlatzElizabeth A. Platz Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins Medical Institutions, Baltimore, Maryland James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)00892-XAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Although inflammation and cell damage due to STIs are hypothesized to contribute to the later development of prostate disease, few clinical studies have been done to investigate the extent to which sexually transmitted agents infect and induce an inflammatory immune response in the prostate. We indirectly investigated this question by measuring serum PSA, a possible marker of prostatic inflammation and cell damage, in men with documented STIs. Materials and Methods: Archived serum specimens from young men with laboratory confirmed exudative STIs, including gonorrhea, chlamydia and trichomonosis, and young men with no STI diagnoses were identified in 2 prospective studies of patients at Baltimore City STI clinics, that is 84 in the STI Transmission and Acquisition Study, and 61 in the Mucosal Immunity Study. Serum specimens from visits before, during and after STI diagnoses in men with at least 1 exudative STI diagnosis and from all visits in men with no STI diagnoses were tested for total PSA concentration. Results: After combining the studies patients with STIs were more likely to have a 40% or greater increase in PSA than patients with no STI diagnoses (32% vs 2%, p <0.01). Conclusions: These findings suggest that STIs may contribute to prostatic inflammation and cell damage in a subset of infected men. Further studies are warranted to replicate study findings and determine host and infection characteristics associated with large PSA increases. References 1 : Gonorrhea in the Male and Female; A Book for Practitioners. Philadelphia: W. B. Saunders Co1935. Google Scholar 2 : Demonstration of Neisseria gonorrhoeae in prostatic fluid after treatment of uncomplicated gonorrhoeal urethritis. Acta Derm Venereol1971; 51: 73. Google Scholar 3 : Asymptomatic gonorrhea in the male. South Med J1964; 57: 688. Google Scholar 4 : Asymptomatic gonorrhea in men: Diagnosis, natural course, prevalence and significance. N Engl J Med1974; 290: 117. Google Scholar 5 : Isolation of Chlamydia trachomatis from the urethra and from prostatic fluid in men with signs and symptoms of acute urethritis. Acta Derm Venereol1981; 61: 456. 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Volume 175Issue 5May 2006Page: 1937-1942 Advertisement Copyright & Permissions© 2006 by American Urological AssociationKeywordsinfectioninflammationsexually transmitted diseasesprostate-specific antigenprostateAcknowledgmentsThe staff and clinicians at the Baltimore City Health Department helped conduct TRAC and MIS, Jeffrey D. Yuenger and Julie A. Giles assisted with archived study specimen identification, Catherine G. Sutcliffe assisted with specimen retrieval and preparation for PSA testing, Rebecca Brotman provided advice on MIS and Dr. Charlotte A. Gaydos assisted with discussion related to the manuscript.MetricsAuthor Information Siobhan Sutcliffe Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author Jonathan M. Zenilman Department of Medicine (Division of Infectious Diseases), Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author Khalil G. Ghanem Department of Medicine (Division of Infectious Diseases), Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author Rosemary A. Jadack College of Nursing and Health Sciences, University of Wisconsin, Eau Claire, Wisconsin More articles by this author Lori J. Sokoll Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author Debra J. Elliott Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author William G. Nelson Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland Department of Pharmacology, Johns Hopkins Medical Institutions, Baltimore, Maryland James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland Financial interest and/or other relationship with CelGenesis, Proquest, Merck and GlaxoSmithKline. More articles by this author Angelo M. De Marzo Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author Stephen R. Cole Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author William B. Isaacs James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author Elizabeth A. Platz Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins Medical Institutions, Baltimore, Maryland James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author Expand All Advertisement PDF downloadLoading ...