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Intracellularly Expressed Single-Domain Antibody against p15 Matrix Protein Prevents the Production of Porcine Retroviruses

2003; American Society for Microbiology; Volume: 77; Issue: 22 Linguagem: Inglês

10.1128/jvi.77.22.12132-12139.2003

1098-5514

Sylvia Dekker, Wendy Toussaint, George Panayotou, Ton de Wit, Pim Visser, Frank Grosveld, Dubravka Drabek,

Virus-based gene therapy research

ABSTRACT The presence of porcine endogenous retroviruses presents a potential risk of transmission of infectious diseases (xenozoonosis) if tissues and organs from genetically modified pigs are to be used in xenotransplantation. Here, we report that intracellular expression of a llama single-domain antibody against p15, the matrix domain protein of the porcine endogenous retrovirus Gag polyprotein, blocks retrovirus production, providing the possibility of eliminating the risk of infection in xenotransplantation.