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The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids

2009; Thieme Medical Publishers (Germany); Volume: 102; Issue: 11 Linguagem: Inglês

10.1160/th08-12-0797

2567-689X

Scott E. Guimond, Joseph Holman, Jeremy E. Turnbull, Robert M. Lauder, David G. Fernig, Timothy R. Rudd, Mark A. Skidmore, Edwin A. Yates,

Hops Chemistry and Applications

Summary The ultraviolet circular dichroism (CD) spectra of commercial low-molecular-weight heparins, heparinoids and other anticoagulant preparations have been recorded between 180 and 260 nm. Principal component analysis of the spectra allowed their differentiation into a number of groups related to the means of their production reflecting the structural changes introduced by each process. The findings suggest that CD provides a complementary technique for the rapid analysis of heparin preparations.