Angiosarcoma of the scalp: absence of vascular endothelial cadherin in primary and metastatic lesions
2001; Oxford University Press; Volume: 144; Issue: 2 Linguagem: Inglês
10.1046/j.1365-2133.2001.04032.x
ISSN1365-2133
AutoresMaki Tanioka, Akihiko Ikoma, Keiko Morita, Hiromasa Fujii, K-I. Toda, Keiichi Takahashi, Tomoko Tanaka, Chikako Nishigori, Gen Ming Jin, S. Higashi, Shinya Toyokuni, Yasutaka Miyachi,
Tópico(s)Sarcoma Diagnosis and Treatment
ResumoA 73‐year‐old man with angiosarcoma of the scalp died about 1 year after disease onset, despite systemic and topical administration of recombinant interleukin‐2. Histopathology showed typical changes of endothelial cells with very sparse lymphocytic infiltration into the tumour. An autopsy revealed that the primary site penetrated cranial bone and invaded vertically into the subarachnoid space. Multiple metastases to lung, chest wall, vertebrae and ribs were also found. On immunofluorescence staining, the expression of vascular endothelial cadherin, which is present in normal endothelium, was absent from both primary and metastatic sites. This may have promoted local invasion and metastasis.
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