Darunavir concentrations exceed the protein-corrected EC50 for wild-type HIV in the semen of HIV-1-infected men
2010; Lippincott Williams & Wilkins; Volume: 24; Issue: 16 Linguagem: Inglês
10.1097/qad.0b013e32833ead18
ISSN1473-5571
AutoresStephen Taylor, Ashini N Jayasuriya, Amanda Berry, G Gilleran, Ngozi E Dufty, Laura Else, David Back, Erasmus Smit,
Tópico(s)HIV/AIDS Research and Interventions
ResumoVariable antiretroviral drug penetration into the genital tract may contribute to the differential evolution of HIV-1 and the emergence of drug resistance. We compared concentrations of darunavir in 34 time-matched blood plasma and seminal plasma samples from 18 HIV-1 positive men. Darunavir in seminal plasma were approximately 10-20% of that achieved in blood at matched time points postdrug ingestion. All seminal plasma darunavir were above the protein-corrected EC₅₀ values for wild-type HIV-1.
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