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Diagnosis and Management of Posttransplant Lymphoproliferative Disorder in Solid‐Organ Transplant Recipients

2001; Oxford University Press; Volume: 33; Issue: s1 Linguagem: Inglês

10.1086/320903

1537-6591

Jutta K. Preiksaitis, Susan Keay,

Transplantation: Methods and Outcomes

The Epstein-Barr virus (EBV) has a pivotal pathophysiologic role in the development of most lymphoproliferative disorders that occur after solid-organ transplantation. The term "EBV-associated posttransplant lymphoproliferative disorder" (PTLD) includes all clinical syndromes of EBV-associated lymphoproliferation, ranging from uncomplicated posttransplant infectious mononucleosis to true malignancies that contain clonal chromosomal abnormalities. PTLDs are historically associated with a high mortality rate in patients who have a monoclonal form of the disorder. Recently described approaches to pathology, diagnosis, treatment, and preventive strategies of PTLD, however, have the potential to improve outcome.