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The ionic currents underlying pacemaker activity in rabbit sino-atrial node: experimental results and computer simulations

1984; Royal Society; Volume: 222; Issue: 1228 Linguagem: Inglês

10.1098/rspb.1984.0067

2053-9193

Hilary F. Brown, Junko Kimura, Denis Noble, Susan Noble, Anne Taupignon,

Electrochemical Analysis and Applications

The membrane currents underlying the pacemaker depolarization have been investigated in rabbit s.a. node preparations using the twomicroelectrode voltage clamp technique. Many of the experimental results have been simulated using a computer model of s.a. node electrical activity. Changes of three time-dependent membrane currents which could contribute to pacemaker depolarization are found to occur in the relevant potential range: decay of the potassium current, i K , and activation of the inward current, it,and of the slow inward current i si