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Latrophilin Signaling Links Anterior-Posterior Tissue Polarity and Oriented Cell Divisions in the C. elegans Embryo

2009; Elsevier BV; Volume: 17; Issue: 4 Linguagem: Inglês

10.1016/j.devcel.2009.08.008

1878-1551

Tobias Langenhan, Simone Prömel, Lamia Mestek, Behrooz Esmaeili, Helen Waller‐Evans, Christian Hennig, Yuji Kohara, Leon Avery, Ioannis Vakonakis, Ralf Schnabel, Andreas Russ,

Circadian rhythm and melatonin

Understanding the mechanisms that coordinate the orientation of cell division planes during embryogenesis and morphogenesis is a fundamental problem in developmental biology. Here we show that the orphan receptor lat-1, a homolog of vertebrate latrophilins, plays an essential role in the establishment of tissue polarity in the C. elegans embryo. We provide evidence that lat-1 is required for the alignment of cell division planes to the anterior-posterior axis and acts in parallel to known polarity and morphogenesis signals. lat-1 is a member of the Adhesion-GPCR protein family and is structurally related to flamingo/CELSR, an essential component of the planar cell polarity pathway. We dissect the molecular requirements of lat-1 signaling and implicate lat-1 in an anterior-posterior tissue polarity pathway in the premorphogenesis stage of C. elegans development.