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Prognostic Significance of Perirenal Infiltration in Renal Cell Carcinoma (<7 cm)

2012; Yonsei University College of Medicine; Volume: 53; Issue: 5 Linguagem: Inglês

10.3349/ymj.2012.53.5.940

1976-2437

Seongyub Oh, Jang-Ho Yoon, Dongil Kang, Heung Lae Cho, Jae-il Chung,

Renal and related cancers

Purpose: Pathologic stage is the most accurate prognostic factor of renal cell carcinoma.We evaluated whether perirenal fat infiltration is a significant factor in tumors 7 cm or less in size.Materials and Methods: We retrospectively reviewed the record of 164 cases of tumors 7 cm or less in size.We divided the patients into two groups according to the presence of perirenal fat infiltration (group A, pT1; group B, pT3a).We evaluated relationships, recurrence-free survival and diseasespecific survival according to clinicopathologic parameters.Statistical differences were calculated by log-rank test.Results: A total 131 patients were included in group A, with a mean age of 55.8 years, average tumor size was 4.2 cm, and a mean follow-up period of 43 months.Group B included 33 patients, with a mean age of 55.9 years, an average tumor size of 4.1 cm, and a mean follow-up period of 38 months.There was no significant difference in disease-specific survival; however, recurrence-free survival showed significantly different between two groups (group A: 95.5%, group B: 84.4%).Conclusion: In this study, perirenal fat infiltration proved to be an independent prognostic factor for predicting diseasefree survival in patients with tumors of 7 cm or less in size.Therefore, as this study showed, the presence of perirenal fat infiltration requires stricter follow-up planning, even in small renal cell carcinoma.