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Pandemic (H1N1) 2009 influenza in the UK: clinical and epidemiological findings from the first few hundred (FF100) cases

2010; Cambridge University Press; Volume: 138; Issue: 11 Linguagem: Inglês

10.1017/s0950268810001366

1469-4409

Estelle McLean, Richard Pebody, Colin Campbell, Mary E. Chamberland, C. HAWKINS, Jonathan S. Nguyen‐Van‐Tam, Isabel Oliver, Gillian Smith, Chikwe Ihekweazu, S Bracebridge, Helen Maguire, Ross Harris, George Kafatos, Peter J White, Edward Wynne-Evans, J. GREEN, Richard Myers, Anthony Underwood, TJ Dallman, Tim Wreghitt, Maria Zambon, Joanna Ellis, Nick Phin, Bobby P. Smyth, James McMenamin, John Watson,

Respiratory viral infections research

SUMMARY The UK was one of few European countries to document a substantial wave of pandemic (H1N1) 2009 influenza in summer 2009. The First Few Hundred (FF100) project ran from April–June 2009 gathering information on early laboratory-confirmed cases across the UK. In total, 392 confirmed cases were followed up. Children were predominantly affected (median age 15 years, IQR 10–27). Symptoms were mild and similar to seasonal influenza, with the exception of diarrhoea, which was reported by 27%. Eleven per cent of all cases had an underlying medical condition, similar to the general population. The majority (92%) were treated with antiviral drugs with 12% reporting adverse effects, mainly nausea and other gastrointestinal complaints. Duration of illness was significantly shorter when antivirals were given within 48 h of onset (median 5 vs . 9 days, P =0·01). No patients died, although 14 were hospitalized, of whom three required mechanical ventilation. The FF100 identified key clinical and epidemiological characteristics of infection with this novel virus in near real-time.