An upconversion nanoparticle – Zinc phthalocyanine based nanophotosensitizer for photodynamic therapy
2014; Elsevier BV; Volume: 35; Issue: 13 Linguagem: Inglês
10.1016/j.biomaterials.2014.01.068
ISSN1878-5905
AutoresLu Xia, Xianggui Kong, Xiaomin Liu, Langping Tu, Youlin Zhang, Yulei Chang, Kai Liu, Dezhen Shen, Huiying Zhao, Hong Zhang,
Tópico(s)Photodynamic Therapy Research Studies
ResumoRecent advances in NIR triggering upconversion-based photodynamic therapy have led to substantial improvements in upconversion-based nanophotosensitizers. How to obtain the high efficiency of singlet oxygen generation under low 980 nm radiation dosage still remains a challenge. A highly efficient nanophotosensitizer, denoted as UCNPs-ZnPc, was constructed for photodynamic therapy, which is based on near infrared (NIR) light upconversion nanoparticle (UCNP) and Zn(II)-phthalocyanine (ZnPc) photosensitizer (PS). The high 1O2 production efficiency came from the enhancement of the 660 nm upconversion emission of NaYF4:Yb3+, Er3+ UCNP with 25% Yb3+ doping, covalent assemblage of UCNP and ZnPc which significantly shortened the distance and enhanced the energy transfer between the two. The high 1O2 production led to a secure and efficient PDT treatment, as evidenced by the in vivo test where UCNPs-ZnPc of 50 mg per kg body weight was locally injected into the liver tumor in mice, a low 980 nm radiation dose of 351 J/cm2 (0.39 W/cm2) and short irradiation duration of 15 min were sufficient to perform image-guided PDT and caused the liver tumor inhibitory ratio of approximately 80.1%. Histological analysis revealed no pathological changes and inflammatory response in heart, lung, kidney, liver or spleen.
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